Allotypic differences in murine mu genes
| Autor: | S. Quester, P.H. Schreier, Alfred L. M. Bothwell |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 1986 |
| Předmět: |
Untranslated region
Genetics Mice Inbred BALB C Base Sequence Immunoglobulin mu-Chains Protein primary structure Molecular cloning Biology Molecular biology Homology (biology) Mice Inbred C57BL Mice Genes Complementary DNA Animals Amino Acid Sequence Allele Codon Immunoglobulin Allotypes Immunoglobulin Heavy Chains Gene Peptide sequence |
| Popis: | We report the complete DNA sequence of a c-DNA clone of the heavy chain mu b allele of the C57BL/6 mouse. Comparisons have been made with the nucleotide sequences of the germ line BALB/c mu a and the plasmacytoma TEPC-183 mu a alleles reported elsewhere over the entire length of the coding and the 3' untranslated region. In contrast to the extensive differences between the gamma 2a a and b alleles we have reported earlier we see a very high degree of homology between the mu alleles. Only one of the nucleotide differences between C57BL/6 mu b and BALB/c mu a leads to an amino acid substitution. This single amino acid exchange must form the allotypic determinant of the mu b allele. A comparison of four different DNA sequences indicates that they are all distinct IgM alleles. |
| Databáze: | OpenAIRE |
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