Microwave radiation leading to shrinkage of dendritic spines in hippocampal neurons mediated by SNK-SPAR pathway
| Autor: | Xin-Ping Xu, Hai-Juan Li, Ji Dong, Zhao Li, Xiao-Hui Gao, Xiangjun Hu, Yong Zou, Yao Binwei, Li-Feng Wang, Peng Ruiyun, Hong-Mei Zhou, Changzhen Wang, Zong-Huan Liu, Wei-Jia Zhi |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Male Silver Staining Dendritic spine Time Factors Dendritic Spines Hippocampus Hippocampal formation Protein Serine-Threonine Kinases 03 medical and health sciences 0302 clinical medicine Microscopy Electron Transmission Homeostatic plasticity Animals RNA Messenger Spar Rats Wistar Maze Learning Microwaves Molecular Biology Shrinkage Neurons Chemistry General Neuroscience GTPase-Activating Proteins Dendritic filopodia Cell biology Rats Up-Regulation 030104 developmental biology Synapses Ultrastructure Neurology (clinical) Disks Large Homolog 4 Protein 030217 neurology & neurosurgery Developmental Biology Signal Transduction |
| Zdroj: | Brain research. 1679 |
| ISSN: | 1872-6240 |
| Popis: | The popularization of microwave raised concerns about its influence on health including cognitive function which is associated greatly with dendritic spines plasticity. SNK-SPAR is a molecular pathway for neuronal homeostatic plasticity during chronically elevated activity. In this study, Wistar rats were exposed to microwaves (30 mW/cm2 for 6 min, 3 times/week for 6 weeks). Spatial learning and memory function, distribution of dendritic spines, ultrastructure of the neurons and their dendritic spines in hippocampus as well as the related critical molecules of SNK-SPAR pathway were examined at different time points after microwave exposure. There was deficiency in spatial learning and memory in rats, loss of spines in granule cells and shrinkage of mature spines in pyramidal cells, accompanied with alteration of ultrastructure of hippocampus neurons. After exposure to 30 mW/cm2 microwave radiation, the up-regulated SNK induced decrease of SPAR and PSD-95, which was thought to cause the changes mentioned above. In conclusion, the microwave radiation led to shrinkage and even loss of dendritic spines in hippocampus by SNK-SPAR pathway, resulting in the cognitive impairments. |
| Databáze: | OpenAIRE |
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