Ability of Lupus Erythematosus Serum to Inactivate Bacteriophage X174 Surviving Treatment with Specific Rabbit Antibody
| Autor: | Bernard U. Bowman, Robert A. Patnode |
|---|---|
| Rok vydání: | 1964 |
| Předmět: |
viruses
Biology Antibodies General Biochemistry Genetics and Molecular Biology Bacteriophage chemistry.chemical_compound medicine Animals Lupus Erythematosus Systemic Bacteriophages Incubation chemistry.chemical_classification Deoxyribonucleases Lupus erythematosus Immune Sera Research Deoxyribonuclease DNA medicine.disease biology.organism_classification Molecular biology Enzyme chemistry Nucleic acid biology.protein Rabbits Antibody |
| Zdroj: | Experimental Biology and Medicine. 115:338-341 |
| ISSN: | 1535-3699 1535-3702 |
| DOI: | 10.3181/00379727-115-28907 |
| Popis: | SummaryAfter 4 to 10 hours of incubation, essentially all the surviving phage in the ⊘X 174 phage-anti-phage system was sensitive to further inactivation by several sera from patients with lupus erythematosus (LE) but they were not sensitive to the enzymatic action of DNase. Phage not previously incubated with specific antiserum was resistant to LE serum and DNase. A hypothesis involving infectious nucleic acid as the underlying mechanism for this behavior is presented. |
| Databáze: | OpenAIRE |
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