Synergism of CAY-1 with Amphotericin B and Itraconazole
| Autor: | John M. Bland, Stephen M. Boue, A.J. De Lucca, C. B. Vigo, Thomas J. Walsh, Thomas E. Cleveland |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Antifungal Agents
Time Factors Itraconazole Aspergillus flavus Microbial Sensitivity Tests Aspergillus fumigatus Microbiology food Drug Resistance Fungal Amphotericin B Candida albicans Drug Discovery medicine Pharmacology (medical) Pharmacology biology Aspergillus niger Drug Synergism General Medicine Saponins biology.organism_classification Corpus albicans food.food Cayenne pepper Drug Combinations Infectious Diseases Oncology Steroids Plant Preparations Capsicum medicine.drug |
| Zdroj: | Chemotherapy. 52:285-287 |
| ISSN: | 1421-9794 0009-3157 |
| DOI: | 10.1159/000095959 |
| Popis: | Background: CAY-1 is a fungicidal saponin from cayenne pepper whose mode of action differs from amphotericin B (AB) and itraconazole (IT). This work determined CAY-1 synergism with AB or IT. Methods: CAY-1 was purified and used in checkerboard microdilution studies where CAY-1 and AB or IT were mixed with nongerminated (NG) and germinating (G) conidia of three Aspergillus species and Candida albicans. Inhibition was visually determined at 24 and 48 h. Results: CAY-1 had predominantly additive-synergistic interaction with AB or IT against the Aspergillus NG and G conidia. Excellent synergy between CAY-1 and AB occurred at 24 and 48 h against C. albicans. Results suggest CAY-1 enhances AB and IT efficacy. |
| Databáze: | OpenAIRE |
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