Status of Anti-Thyroid Peroxidase During Normal Pregnancy and in Patients with Hyperemesis Gravidarum
| Autor: | C. Y. Li, Michael S. Rogers, N.S. Panesar, K.W. Chan |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Adult
China endocrine system medicine.medical_specialty endocrine system diseases Endocrinology Diabetes and Metabolism medicine.medical_treatment Iodide Peroxidase Gastroenterology Thyroiditis Cohort Studies Hyperemesis gravidarum Endocrinology Pregnancy Reference Values Thyroid peroxidase Hyperemesis Gravidarum Internal medicine medicine Humans Gynecology biology business.industry Thyroid Thyroiditis Autoimmune Middle Aged medicine.disease Thyroid Diseases Pregnancy Complications medicine.anatomical_structure Case-Control Studies Cohort biology.protein Female Thyroglobulin Thyroid function Myxedema business |
| Zdroj: | Thyroid. 16:481-484 |
| ISSN: | 1557-9077 1050-7256 |
| DOI: | 10.1089/thy.2006.16.481 |
| Popis: | Autoimmune thyroid diseases (AITD) comprising Hashimoto's thyroiditis, primary myxedema, and Graves' disease are associated with autoantibodies directed against thyroglobulin and thyroid peroxidase (anti-TPO). Anti-TPO occur in 10% of pregnant women, half of whom reportedly develop postpartum thyroid dysfunction. We recently published data on the thyroid function reference ranges in pregnant Chinese but the AITD status of our cohort was unknown. In view of this missing information we have measured anti-TPO in specimens from our cohort stored at -80 degrees C, and compared these to those of patients with hyperemesis gravidarum (HG) and nonpregnant controls. After eliminating 3 outliers from 47 nonpregnant controls, the anti-TPO concentration range was 2.2-14.7 kIU/L (n = 44). In 282 pregnant control subjects, the anti-TPO levels were less than 14.7 kIU/L (upper limit of nonpregnant controls) in 189 (67%); between 14.7-55 kIU/L in 82 (29.1%); and greater than 55 kIU/L in 11 (3.9%). The percentage of women with anti-TPO greater than 14.7 kIU/L during the first, second, and third trimesters were 47% (30/64), 39% (49/126), and 16% (15/92), respectively. Anti-TPO level was significantly higher in pregnant controls compared to nonpregnant controls and patients with HG. With reference to other studies in which anti-TPO levels greater than 60 kIU/L were considered pathologic, we conclude that more than 96% of our pregnant controls were without AITD and the data on thyroid function reference ranges we previously reported remain valid. |
| Databáze: | OpenAIRE |
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