Correlating Clinical Risk Factors and Histological Features in Ruptured and Unruptured Human Intracranial Aneurysms: The Swiss AneuX Study

Autor: Karl Lothard Schaller, Marie-Luce Bochaton-Piallat, Esther Sutter, Renato Gondar, Philippe Bijlenga, Vincent Braunersreuther, Marco Vincenzo Corniola, Nicolas Dupuy, Mannekomba Roxane Diagbouga, Max Jägersberg, Brenda R. Kwak, Sandrine Morel, Graziano Pelli, Nathalie Isidor
Rok vydání: 2018
Předmět:
Adult
Male
0301 basic medicine
Pathology
medicine.medical_specialty
ddc:616.07
Aneurysm
Ruptured
Type distribution
Muscle
Smooth
Vascular
Magnetic resonance angiography
Pathology and Forensic Medicine
03 medical and health sciences
Cellular and Molecular Neuroscience
0302 clinical medicine
Aneurysm
Smooth muscle
Risk Factors
medicine
Humans
cardiovascular diseases
medicine.diagnostic_test
biology
business.industry
Macrophages
Smoking
Endothelial Cells
Intracranial Aneurysm
General Medicine
Middle Aged
medicine.disease
University hospital
Immunohistochemistry
ddc:616.8
Cerebral Angiography
Elastin
030104 developmental biology
Neurology
cardiovascular system
biology.protein
Female
Collagen
Neurology (clinical)
business
Clinical risk factor
Magnetic Resonance Angiography
030217 neurology & neurosurgery
Cerebral angiography
Zdroj: Journal of Neuropathology and Experimental Neurology, Vol. 77, No 7 (2018) pp. 555-566
ISSN: 1554-6578
0022-3069
Popis: Pathogenesis of intracranial aneurysm is complex and the precise biomechanical processes leading to their rupture are uncertain. The goal of our study was to characterize the aneurysmal wall histologically and to correlate histological characteristics with clinical and radiological factors used to estimate the risk of rupture. A new biobank of aneurysm domes resected at the Geneva University Hospitals (Switzerland) was used. Histological analysis revealed that unruptured aneurysms have a higher smooth muscle cell (SMC) content and a lower macrophage content than ruptured domes. These differences were associated with more collagen in unruptured samples, whereas the elastin content was not affected. Collagen content and type distribution were different between thick and thin walls of unruptured aneurysms. Classification of aneurysm domes based on histological characteristics showed that unruptured samples present organized wall rich in endothelial and SMCs compared with ruptured samples. Finally, aneurysm wall composition was altered in unruptured domes of patients presenting specific clinical factors used to predict rupture such as large dome diameter, dome irregularities, and smoking. Our study shows that the wall of aneurysm suspected to be at risk for rupture undergoes structural alterations relatively well associated with clinical and radiological factors currently used to predict this risk.
Databáze: OpenAIRE
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