Correlating Clinical Risk Factors and Histological Features in Ruptured and Unruptured Human Intracranial Aneurysms: The Swiss AneuX Study
Autor: | Karl Lothard Schaller, Marie-Luce Bochaton-Piallat, Esther Sutter, Renato Gondar, Philippe Bijlenga, Vincent Braunersreuther, Marco Vincenzo Corniola, Nicolas Dupuy, Mannekomba Roxane Diagbouga, Max Jägersberg, Brenda R. Kwak, Sandrine Morel, Graziano Pelli, Nathalie Isidor |
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Rok vydání: | 2018 |
Předmět: |
Adult
Male 0301 basic medicine Pathology medicine.medical_specialty ddc:616.07 Aneurysm Ruptured Type distribution Muscle Smooth Vascular Magnetic resonance angiography Pathology and Forensic Medicine 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine Aneurysm Smooth muscle Risk Factors medicine Humans cardiovascular diseases medicine.diagnostic_test biology business.industry Macrophages Smoking Endothelial Cells Intracranial Aneurysm General Medicine Middle Aged medicine.disease University hospital Immunohistochemistry ddc:616.8 Cerebral Angiography Elastin 030104 developmental biology Neurology cardiovascular system biology.protein Female Collagen Neurology (clinical) business Clinical risk factor Magnetic Resonance Angiography 030217 neurology & neurosurgery Cerebral angiography |
Zdroj: | Journal of Neuropathology and Experimental Neurology, Vol. 77, No 7 (2018) pp. 555-566 |
ISSN: | 1554-6578 0022-3069 |
Popis: | Pathogenesis of intracranial aneurysm is complex and the precise biomechanical processes leading to their rupture are uncertain. The goal of our study was to characterize the aneurysmal wall histologically and to correlate histological characteristics with clinical and radiological factors used to estimate the risk of rupture. A new biobank of aneurysm domes resected at the Geneva University Hospitals (Switzerland) was used. Histological analysis revealed that unruptured aneurysms have a higher smooth muscle cell (SMC) content and a lower macrophage content than ruptured domes. These differences were associated with more collagen in unruptured samples, whereas the elastin content was not affected. Collagen content and type distribution were different between thick and thin walls of unruptured aneurysms. Classification of aneurysm domes based on histological characteristics showed that unruptured samples present organized wall rich in endothelial and SMCs compared with ruptured samples. Finally, aneurysm wall composition was altered in unruptured domes of patients presenting specific clinical factors used to predict rupture such as large dome diameter, dome irregularities, and smoking. Our study shows that the wall of aneurysm suspected to be at risk for rupture undergoes structural alterations relatively well associated with clinical and radiological factors currently used to predict this risk. |
Databáze: | OpenAIRE |
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