Preliminary Insights in Oxytocin Association with the Onset of Diabetic Neuropathy
| Autor: | O. I. Geicu, L. Kobylinska, Monica Neagu, Constantin Caruntu, I. Dobrescu, Carolina Constantin, Mihaela Ghita, Leon Zagrean, G. Gabreanu, Bădescu Sv, Calin Petru Tataru |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Diabetic neuropathy Endocrinology Diabetes and Metabolism Substance P Notes & Comments 03 medical and health sciences chemistry.chemical_compound Orexin-A Endocrinology Internal medicine Diabetes mellitus medicine In patient Type 1 diabetes Endocrine and Autonomic Systems business.industry medicine.disease 030104 developmental biology chemistry Oxytocin business hormones hormone substitutes and hormone antagonists Neurotensin medicine.drug |
| Zdroj: | Acta Endocrinologica (Bucharest). 13:249-253 |
| ISSN: | 1843-066X 1841-0987 |
| DOI: | 10.4183/aeb.2017.249 |
| Popis: | Diabetes is one of the most prevalent chronic disorders, associating numerous somatic and behavioral modifications. Oxytocin has been widely studied for its involvement in social behavior and psychiatric disorders. This pilot study presents a series of 3 patients with type 1 diabetes and diabetic neuropathy in which the values of plasma oxytocin, neurotensin, β-endorphins, α-MSH, substance P and orexin A were measured in comparison to 3 healthy controls with matching ages. In the diabetic patients group, there was a strong negative correlation between the value of plasma glucose and oxytocin (r=-0.99, p=0.04), respectively neurotensin (r=-0.99, p=0.03). These values did not correlate in the control group. The results suggest that oxytocin, in conjunction with neurotensin, could be investigated as a potential early detection marker of diabetic neuropathy and, to our knowledge, this is the first report focusing on plasma oxytocin levels in patients with diabetic neuropathy. |
| Databáze: | OpenAIRE |
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