Effects of the cannabinoid CB1 receptor antagonist AM 251 on the reinstatement of nicotine-conditioned place preference by drug priming in rats
| Autor: | Barbara Budzyńska, Grazyna Biala, Marta Kruk |
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| Rok vydání: | 2008 |
| Předmět: |
Drug
Male Nicotine Cannabinoid receptor media_common.quotation_subject medicine.medical_treatment Pharmacology Extinction Psychological Piperidines Receptor Cannabinoid CB1 Conditioning Psychological medicine Animals Rats Wistar Receptor media_common Dose-Response Relationship Drug business.industry Antagonist General Medicine Extinction (psychology) Conditioned place preference Rats Pyrazoles lipids (amino acids peptides and proteins) Cannabinoid business medicine.drug |
| Zdroj: | Pharmacological reports : PR. 61(2) |
| ISSN: | 1734-1140 |
| Popis: | Tobacco and cannabis are among the most widely abused drugs in humans, and recently, the functional interaction between nicotine and cannabinoids has been reported. The aim of the present studies is to evaluate the role of CB1 cannabinoid receptors in the reinstatement of nicotine-induced conditioned place preference. Nicotine-induced conditioned place preference was established (three-day nicotine sessions, 0.5 mg/kg), extinguished and reinstated by a priming dose of nicotine. It was shown that the CB1 receptor antagonist AM 251 (0.25 and 0.5 mg/kg) in a dose-dependent manner attenuates the reinstatement of nicotine place conditioning. These studies suggest a role for CB1 cannabinoids receptors in preventing the reinstatement of nicotine addiction. |
| Databáze: | OpenAIRE |
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