Impact of procedural characteristics on coronary vessel wall healing following implantation of second-generation drug-eluting absorbable metal scaffold in patients with de novo coronary artery lesions: an optical coherence tomography analysis
| Autor: | Alexandre Hideo-Kajita, Jouke Dijkstra, Pedro A. Lemos, Ralph Tölg, Yuichi Ozaki, Clemens von Birgelen, Javier Escaned, Evald Høj Christiansen, Hector M. Garcia-Garcia, William Wijns, Hüseyin Ince, Kayode O. Kuku, Michael Haude, Alexandre Abizaid, Ron Waksman |
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| Přispěvatelé: | Health Technology & Services Research |
| Rok vydání: | 2018 |
| Předmět: |
Male
Scaffold MULTICENTER Drug-eluting absorbable metal scaffold 030204 cardiovascular system & hematology 0302 clinical medicine Absorbable Implants BIOSOLVE-II Prospective Studies OUTCOMES BIORESORBABLE SCAFFOLDS Luminal volume loss medicine.diagnostic_test Drug-Eluting Stents Equipment Design General Medicine STENTS Middle Aged Coronary Vessels INSIGHTS medicine.anatomical_structure luminal volume loss Coronary vessel Female drug-eluting absorbable metal scaffold Cardiology and Cardiovascular Medicine Volume loss Tomography Optical Coherence Artery Adult 03 medical and health sciences Optical coherence tomography Side branch medicine Humans Optical Coherence Tomography (OCT) Radiology Nuclear Medicine and imaging In patient DREAMS Aged Sirolimus Wound Healing optical coherence tomography business.industry PERFORMANCE SUSTAINED SAFETY n/a OA procedure Nuclear medicine business Bioresorbable scaffold |
| Zdroj: | European Heart Journal Cardiovascular Imaging, 20(8), 916-924. Oxford University Press Ozaki, Y, Garcia-Garcia, H M, Hideo-Kajita, A, Kuku, K O, Haude, M, Ince, H, Abizaid, A, Tölg, R, Lemos, P A, von Birgelen, C, Christiansen, E H, Wijns, W, Escaned, J, Dijkstra, J & Waksman, R 2019, ' Impact of procedural characteristics on coronary vessel wall healing following implantation of second-generation drug-eluting absorbable metal scaffold in patients with de novo coronary artery lesions : an optical coherence tomography analysis ', European Heart Journal Cardiovascular Imaging, vol. 20, no. 8, pp. 916-924 . https://doi.org/10.1093/ehjci/jey210 European Heart Journal-Cardiovascular Imaging, 20(8), 916-924 |
| ISSN: | 2047-2412 2047-2404 |
| DOI: | 10.1093/ehjci/jey210 |
| Popis: | Aims Second-generation drug-eluting absorbable metal scaffold (DREAMS 2G) is an alternative novel device for treating coronary lesions. However, the relationship between in-scaffold dimensions after implantation of DREAMS 2G and vessel healing and luminal results at follow-up is unknown. The aim of this study is, therefore, to investigate whether the expansion index after implantation of DREAMS 2G as assessed by optical coherence tomography (OCT) impacts late luminal status and healing of the vessel wall. Methods and results This study comprises of a total 65 out of 123 patients who were enrolled in the BIOSOLVE-II trial. We assessed both qualitative and quantitative OCT findings and the expansion index of DREAMS 2G after implantation frame by frame using OCT. Expansion index was defined as minimum scaffold area/mean reference lumen area. The over-expansion group was also defined with expansion index >1.0. The total number of analysed frames at post-procedure and 6-month follow-up was 8243 and 8263 frames, respectively. At 6-month follow-up, in-scaffold healing was documented by the reduction of 82% in dissections, 93% in attached intra-luminal mass (ILM), 65% in non-attached ILM, and 76% in jailed side branch. The over-expansion group had significantly greater in-scaffold luminal volume loss (LVL) compared with the non-over-expansion group [over-expansion: 35.0 (18.5–52.1) mm3 vs. non-over-expansion: 21.0 (11.6–37.9) mm3, P = 0.039]. Conclusion Excellent in vivo healing process after implantation of DREAMS 2G was observed at 6 months. We found that higher expansion indices were associated with higher in-scaffold LVL at 6 months assessed by OCT. |
| Databáze: | OpenAIRE |
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