Adipose tissue plasticity and the pleiotropic roles of BMP signaling
| Autor: | Yan Tang, Shuwen Qian, Qi Qun Tang |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Transcription Genetic BMPs Adipose tissue White adipose tissue Biochemistry ATM adipose tissue macrophage chemistry.chemical_compound Adipocyte Brown adipose tissue Adipocytes TGF transforming growth factor Cellular Senescence Cell Death Cell Differentiation WAT white adipose tissue Thermogenin Cell biology TNFα tumor necrosis factor α medicine.anatomical_structure Adipose Tissue Adipogenesis Bone Morphogenetic Proteins Signal Transduction Adipose tissue macrophages macrophage Biology Bone morphogenetic protein adipocyte PPARγ proliferator-activated receptor gamma adipogenesis 03 medical and health sciences UCP1 uncoupling protein 1 medicine Animals Humans Molecular Biology Zfp423 zinc-finger protein 423 030102 biochemistry & molecular biology Macrophages JBC Reviews HALS highly active antiretroviral treatment–associated lipodystrophy syndrome GDF growth/differentiation factor BMP bone morphogenetic protein Cell Biology IL interleukin BAT brown adipose tissue PDGFRβ platelet-derived growth factor receptor beta 030104 developmental biology chemistry plasticity beige |
| Zdroj: | The Journal of Biological Chemistry |
| ISSN: | 1083-351X |
| Popis: | Adipose tissues, including white, beige, and brown adipose tissue, have evolved to be highly dynamic organs. Adipose tissues undergo profound changes during development and regeneration and readily undergo remodeling to meet the demands of an everchanging metabolic landscape. The dynamics are determined by the high plasticity of adipose tissues, which contain various cell types: adipocytes, immune cells, endothelial cells, nerves, and fibroblasts. There are numerous proteins that participate in regulating the plasticity of adipose tissues. Among these, bone morphogenetic proteins (BMPs) were initially found to regulate the differentiation of adipocytes, and they are being reported to have pleiotropic functions by emerging studies. Here, in the first half of the article, we summarize the plasticity of adipocytes and macrophages, which are two groups of cells targeted by BMP signaling in adipose tissues. We then review how BMPs regulate the differentiation, death, and lipid metabolism of adipocytes. In addition, the potential role of BMPs in regulating adipose tissue macrophages is considered. Finally, the expression of BMPs in adipose tissues and their metabolic relevance are discussed. |
| Databáze: | OpenAIRE |
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