Mitomycin-C– or Cisplatin-Based Chemoradiotherapy for Anal Canal Carcinoma: Long-Term Results
| Autor: | Marcos A. Bezerra, Luis O. Olivatto, José Humberto Simões, Arthur Accioly Rosa, Vânia Cabral, Carlos Gil Ferreira, Ana Fassizoli, Leonaldson Castro, Isabele Avila Small, Erick Santarem |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Adult
Male Cancer Research medicine.medical_specialty Mitomycin medicine.medical_treatment Rectum Gastroenterology Sex Factors Internal medicine Antineoplastic Combined Chemotherapy Protocols Colostomy medicine Humans Radiology Nuclear Medicine and imaging Large intestine Survival rate Aged Randomized Controlled Trials as Topic Retrospective Studies Salvage Therapy Cisplatin Analysis of Variance Chemotherapy Radiation business.industry Mitomycin C Radiotherapy Dosage Middle Aged Anus Neoplasms Combined Modality Therapy Surgery Radiation therapy medicine.anatomical_structure Oncology Female business Chemoradiotherapy Follow-Up Studies medicine.drug |
| Zdroj: | International Journal of Radiation Oncology*Biology*Physics. 79:490-495 |
| ISSN: | 0360-3016 |
| Popis: | Purpose: To evaluate the long-term efficacy of concurrent radiotherapy with mitomycin-C (MMC)-based or cisplatin (CP)-based combinations in a cohort of patients with locally advanced anal canal carcinoma. Methods and Materials: Between 1988 and 2000, 179 patients with locally advanced anal canal carcinoma were treated at the Instituto Nacional de Cancer with two cycles of chemotherapy during Weeks 1 and 5 of radiotherapy. 5-Fluorouracil (750 mg/m{sup 2} 120-hour infusion or 1,000 mg/m{sup 2} 96-hour infusion) plus CP (100 mg/m{sup 2}) on the first day of each cycle or MMC (10-15 mg/m{sup 2}) on the first day of Cycle 1 was administered concurrent with radiotherapy (total dose, 55-59.4 Gy). Of the 179 patients, 60% were included from a randomized trial initiated at the Instituto Nacional de Cancer in 1991 that compared concurrent chemoradiotherapy with MMC vs. CP. Results: The median follow-up for the whole chemoradiotherapy group was 83 months. The median patient age was 58 years, 57% had Stage T3-T4 tumors, and 35% had N-positive disease. The 5-year cumulative colostomy rate was not significantly different between the CP group (22%) and MMC group (29%; p = .28). The actuarial 10-year overall survival and disease-free survival rate for the CP group was 54%more » and 49% and for the MMC group was 52% and 53%, respectively (p = .32 and p = .92, respectively). On multivariate analysis, male gender (p = .042) and advanced Stage T3-T4 disease (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|