Genome Analysis Linking Recent European and African Influenza (H5N1) Viruses
| Autor: | Ian H. Brown, David J. Spiro, Annalisa Guercio, Daniel Janies, Magdi D. Saad, Ilaria Capua, Elodie Ghedin, Steven L. Salzberg, Do Huu Dung, Olga Zorman-Rojs, Mona M. Aly, Gian Mario De Mia, Iolanda Padalino, Jennifer Zaborsky, Giovanni Cattoli, Vladimir Savić, Azizullah Osmani, Samuel L. Yingst, Tony M. Joannis, Carl Kingsford, Emmanuel Couacy-Hymann, Ali Safar Maken Ali, Naomi Sengamalay |
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| Rok vydání: | 2007 |
| Předmět: |
Microbiology (medical)
sequence analysis Genes Viral Epidemiology viruses Lineage (evolution) Molecular Sequence Data lcsh:Medicine Zoology Biology medicine.disease_cause Genome lcsh:Infectious and parasitic diseases Birds Evolution Molecular Middle East Africa Northern Phylogenetics evolution genomics medicine Animals lcsh:RC109-216 molecular Avian flu data migratory waterfowl Asia outbreak reveals Phylogeny Molecular Epidemiology Influenza A Virus H5N1 Subtype Molecular epidemiology Research lcsh:R Outbreak Influenza a DNA Influenza A virus subtype H5N1 Europe Infectious Diseases Highly Pathogenic Avian Influenza Virus Influenza A virus Evolutionary biology Influenza in Birds |
| Zdroj: | Scopus-Elsevier Emerging Infectious Diseases Emerging Infectious Diseases, Vol 13, Iss 5, Pp 713-713 (2007) Europe PubMed Central ResearcherID |
| ISSN: | 1080-6059 1080-6040 |
| DOI: | 10.3201/eid1305.070013 |
| Popis: | Although linked, these viruses are distinct from earlier outbreak strains. To better understand the ecology and epidemiology of the highly pathogenic avian influenza virus in its transcontinental spread, we sequenced and analyzed the complete genomes of 36 recent influenza A (H5N1) viruses collected from birds in Europe, northern Africa, and southeastern Asia. These sequences, among the first complete genomes of influenza (H5N1) viruses outside Asia, clearly depict the lineages now infecting wild and domestic birds in Europe and Africa and show the relationships among these isolates and other strains affecting both birds and humans. The isolates fall into 3 distinct lineages, 1 of which contains all known non-Asian isolates. This new Euro-African lineage, which was the cause of several recent (2006) fatal human infections in Egypt and Iraq, has been introduced at least 3 times into the European-African region and has split into 3 distinct, independently evolving sublineages. One isolate provides evidence that 2 of these sublineages have recently reassorted. |
| Databáze: | OpenAIRE |
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