Polymorphisms of Arylamine N-Acetyltransferase (NAT1 and NAT2) and Larynx Cancer Susceptibility
Autor: | Carlos Lopes, Regina Silva, Carlos Pinheiro, Graça Varzim, Eurico Monteiro |
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Rok vydání: | 2002 |
Předmět: |
Adult
Male Larynx medicine.medical_specialty Genotype Arylamine N-Acetyltransferase Gastroenterology Acetyltransferases Risk Factors Internal medicine medicine Humans Genetic Predisposition to Disease Laryngeal Neoplasms Alleles Aged Aged 80 and over Arylamine N-acetyltransferase business.industry Cancer Odds ratio Middle Aged medicine.disease Confidence interval Genotype frequency Isoenzymes Endocrinology medicine.anatomical_structure Otorhinolaryngology Epidermoid carcinoma Female business Polymorphism Restriction Fragment Length |
Zdroj: | ORL. 64:206-212 |
ISSN: | 1423-0275 0301-1569 |
Popis: | Our aim was to examine the role of NAT1 and NAT2 polymorphisms in human larynx cancer susceptibility. Genotype tests for NAT1 alleles *4, *10 and *11, and NAT2 alleles *4, *5, *6A and *7A, using PCR-RFLP analysis, were performed in 172 healthy Portuguese individuals and 88 patients with squamous cell carcinoma of the larynx. NAT1 and NAT2 genotype frequencies were correlated between patients and control groups, using the chi-square test. Odds ratios and 95% confidence intervals were calculated from 2 × 2 tables with the Fisher’s exact model. The statistical analysis of NAT1 and NAT2 genotype frequencies revealed a significant difference of NAT1*10/*11 (p = 0.038) and NAT2*5/*7 (p = 0.003) genotype distribution between cases and controls. We also observed differences concerning tumor location, since NAT1*10/*11 genotype frequency was significantly different when comparing normal control individuals with the glottic subgroup of patients. The present data suggest that NAT1 and NAT2 polymorphisms may be correlated with an increased risk of larynx cancer. |
Databáze: | OpenAIRE |
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