Novel Series of O-substituted 8-quinolines and 4-benzothiazoles as potent antagonists of the bradykinin B2 receptors
| Autor: | Wagner Adalbert, Bernward A. Schölkens, Klaus Wirth, Holger Heitsch |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Receptor
Bradykinin B2 Stereochemistry Clinical Biochemistry Pharmaceutical Science Bradykinin Biochemistry Chemical synthesis Structure-Activity Relationship chemistry.chemical_compound Drug Discovery medicine Structure–activity relationship Benzothiazoles Bradykinin receptor Receptor Molecular Biology Bradykinin Receptor Antagonists Bradykinin B2 Receptor Antagonists Chemistry Organic Chemistry In vitro Thiazoles Quinolines Molecular Medicine medicine.symptom Vasoconstriction |
| Zdroj: | Bioorganic & Medicinal Chemistry Letters. 9:327-332 |
| ISSN: | 0960-894X |
| DOI: | 10.1016/s0960-894x(98)00736-7 |
| Popis: | The synthesis and the SAR study of novel O-substituted 8-quinolines and 4-benzothiazoles as highly potent non-peptide bradykinin B2 receptor antagonists are described. Several members of this series of antagonists efficiently inhibited the BK-induced vasoconstriction on different isolated organ preparations. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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