Immune responses against human papillomavirus (HPV) type 16 virus-like particles in a cohort study of women with cervical intraepithelial neoplasia. I. Differential T-helper and IgG responses in relation to HPV infection and disease outcome

Autor: R.J. Scheper, Theo J.M. Helmerhorst, J. M. M. Walboomers, R.H.M. Verheijen, M. J. Stukart, Esther W. M. Kueter, T. D. De Gruijl, Peter L. Stern, Pierre Coursaget, C. Dupuy, Margaret F Duggan-Keen, C. J. L. M. Meijer, H. J. Bontkes
Přispěvatelé: Laboratoire d'Immunologie des Maladies Infectieuses [Tours], Université de Tours (UT), Université de Tours, Obstetrics & Gynecology, Medical oncology laboratory, CCA - Cancer biology and immunology, CCA - Imaging and biomarkers, CCA - Cancer Treatment and quality of life, Laboratory Medicine, AGEM - Endocrinology, metabolism and nutrition, Obstetrics and gynaecology, Amsterdam Neuroscience - Cellular & Molecular Mechanisms, AII - Cancer immunology, Pathology
Rok vydání: 1999
Předmět:
viruses
Uterine Cervical Neoplasms
Antibodies
Viral
Epitope
Cohort Studies
Epitopes
0302 clinical medicine
HLA-DQ beta-Chains
Prospective cohort study
Antigens
Viral
Papillomaviridae
HLA-DRB1
ComputingMilieux_MISCELLANEOUS
0303 health sciences
HPV infection
virus diseases
T-Lymphocytes
Helper-Inducer
female genital diseases and pregnancy complications
3. Good health
030220 oncology & carcinogenesis
[SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology
Female
Adult
Genotype
Molecular Sequence Data
Biology
Cervical intraepithelial neoplasia
Virus
03 medical and health sciences
Immune system
SDG 3 - Good Health and Well-being
HLA-DQ Antigens
Virology
medicine
Humans
Amino Acid Sequence
030304 developmental biology
Papillomavirus Infections
Haplotype
HLA-DR Antigens
Oncogene Proteins
Viral
Uterine Cervical Dysplasia
medicine.disease
Tumor Virus Infections
Haplotypes
Immunoglobulin G
Immunology
Interleukin-2
Capsid Proteins
HLA-DRB1 Chains
Zdroj: Journal of General Virology
Journal of General Virology, Microbiology Society, 1999, 80 (2), pp.399-408. ⟨10.1099/0022-1317-80-2-399⟩
Journal of General Virology, 80, 399-408. Microbiology Society
de Gruijl, T D, Bontkes, H J, Walboomers, J M, Coursaget, P, Stukart, M J, Dupuy, C, Kueter, E, Verheijen, R H, Helmerhorst, T J, Duggan-Keen, M F, Stern, P L, Meijer, C J & Scheper, R J 1999, ' Immune responses against human papillomavirus (HPV) type 16 virus-like particles in a cohort study of women with cervical intraepithelial neoplasia. I. Differential T-helper and IgG responses in relation to HPV infection and disease outcome ', Journal of General Virology, vol. 80 ( Pt 2), pp. 399-408 . https://doi.org/10.1099/0022-1317-80-2-399
Journal of General Virology, 80 ( Pt 2), 399-408. Society for General Microbiology
ISSN: 1465-2099
0022-1317
DOI: 10.1099/0022-1317-80-2-399
Popis: T-helper (Th) cell-dependent IL-2 production and plasma IgG responses to virus-like particles consisting of the human papillomavirus type 16 (HPV-16) major capsid protein L1 (L1-VLP) were determined in patients with cytological evidence of cervical intraepithelial neoplasia (CIN) participating in a non-intervention prospective cohort study. IgG responses were associated with HPV-16 persistence and high-grade CIN lesions, while high frequencies of Th responses were observed in patients with both virus clearance and virus persistence, irrespective of CIN grade. The IgG response was found in conjunction with an IL-2 response to L1-VLP in 87% of the patients. Recognition of the HPV-16 L1 Th epitope (amino acids 311-335) was found to be more closely associated than recognition of L1-VLP as a whole to HPV exposure and CIN development. Among the HPV-16+ patients included in this study, those showing a Th response to amino acids 311-335 were more likely to carry the HLA DRB1*11/DQB1*0301 haplotype, while those showing an IgG response to L1-VLP were more likely to carry DRB1*0101/DQB1*0501. However, neither cell-mediated nor humoral immune responses against HPV-16 L1 appear to be sufficient for the natural control of HPV infection and CIN development.
Databáze: OpenAIRE
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