Two cases of melanomas paradoxically metastasizing to the intestinal tract during nivolumab therapy
Autor: | Teruki Yanagi, Nobuki Ichikawa, Jiro Uehara, Hideki Kawamura, Akinobu Taketomi, Yosuke Ohno, Yasuyuki Yamaguchi, Shigenori Homma, Hiroo Hata, Hajime Miyazawa, Keisuke Imafuku, Hiroshi Shimizu, Shinya Kitamura, Tadashi Yoshida |
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Jazyk: | angličtina |
Rok vydání: | 2017 |
Předmět: |
Male
Pathology Lung Neoplasms Skin Neoplasms fecal occult blood test Vitiligo Endoscopy Gastrointestinal law.invention 0302 clinical medicine Fatal Outcome law 030212 general & internal medicine Lymph node Melanoma Skin Aged 80 and over Ileocecal Valve Antibodies Monoclonal General Medicine Colonoscopy Dacarbazine medicine.anatomical_structure C-Reactive Protein 030220 oncology & carcinogenesis Lymphatic Metastasis Occult Blood Colonic Neoplasms Female Nivolumab medicine.medical_specialty Anemia malignant melanoma Antineoplastic Agents Dermatology 03 medical and health sciences Ileocecal valve Capsule endoscopy medicine Humans nivolumab business.industry Fecal occult blood medicine.disease intestinal metastasis weight loss business Tomography X-Ray Computed Intussusception |
Zdroj: | Journal of dermatology. 44(8):959-962 |
ISSN: | 0385-2407 |
Popis: | We report two cases of melanomas in patients who developed intestinal metastasis despite other metastatic sites responding to nivolumab and despite the patients having favorable findings such as vitiligo and normal lactate dehydrogenase. The first case is an 85-year-old man who had been administrated nivolumab for lung/cutaneous metastases. After 22 courses of nivolumab therapy, fever and anorexia had appeared and his bodyweight had decreased. An intussusception on the ileocecal valve was revealed by computed tomography, and emergency surgery revealed metastatic lesions on the colon. The second case is an 87-year-old woman treated with nivolumab for lymph node metastases. After 10 courses, laboratory tests had revealed anemia and positive fecal occult blood. Her bodyweight had decreased. Capsule endoscopy showed scattered tumors and clots, indicating metastases of melanoma. The frequency of symptomatic intestinal metastasis of melanoma is very low. Further, intestinal metastasis of melanoma is difficult to detect through routine examinations. Our cases suggest that fecal occult blood test and decreased bodyweight are indications of intestinal metastases. |
Databáze: | OpenAIRE |
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