The occurrence of hyponatremia and its importance as a prognostic factor in a cross-section of cancer patients
| Autor: | Ilya G. Glezerman, Beni A. Tidwell, Joseph Chiodo, Jorge J. Castillo, Susan Boklage, Kathy L. Schulman, Lois Lamerato |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Male
0301 basic medicine Oncology Cancer Research Lung Neoplasms Lymphoma Survival 0302 clinical medicine Carcinoma Non-Small-Cell Lung Neoplasms Longitudinal Studies Cancer Hypervolemic Incidence Euvolemic Incidence (epidemiology) Chemoradiotherapy Middle Aged Prognosis 030220 oncology & carcinogenesis Female Colorectal Neoplasms Hyponatremia Research Article Adult medicine.medical_specialty Breast Neoplasms Malignancy 03 medical and health sciences Internal medicine Genetics medicine Humans Lung cancer Aged Proportional Hazards Models Retrospective Studies business.industry Proportional hazards model nutritional and metabolic diseases medicine.disease Small Cell Lung Carcinoma United States 030104 developmental biology business |
| Zdroj: | BMC Cancer |
| ISSN: | 1471-2407 |
| Popis: | Background Hyponatremia is prognostic of higher mortality in some cancers but has not been well studied in others. We used a longitudinal design to determine the incidence and prognostic importance of euvolemic and hypervolemic hyponatremia in patients following diagnosis with lymphoma, breast (BC), colorectal (CRC), small cell lung (SCLC), or non-small cell lung cancer (NSCLC). Methods Medical record and tumor registry data from two large integrated delivery networks were combined for patients diagnosed with lymphoma, BC, CRC, or lung cancers (2002–2010) who had ≥1 administration of radiation/chemotherapy within 6 months of diagnosis and no evidence of hypovolemic hyponatremia. Hyponatremia incidence was measured per 1000 person-years (PY). Cox proportional hazard models assessed the prognostic value of hyponatremia as a time-varying covariate on overall survival (OS) and progression-free survival (PFS). Results Hyponatremia incidence (%, rate) was 76 % each, 1193 and 2311 per 1000 PY, among NSCLC and SCLC patients, respectively; 37 %, 169 in BC; 64 %, 637 in CRC, and 60 %, 395 in lymphoma. Hyponatremia was negatively associated with OS in BC (HR 3.7; P = |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|