Alveolar–capillary reserve during exercise in patients with chronic obstructive pulmonary disease
| Autor: | Alberto Avolio, Bruce D. Johnson, Courtney M. Wheatley, Mehrdad Behnia |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Spirometry
COPD medicine.medical_specialty medicine.diagnostic_test business.industry General Medicine Exercise intolerance 030204 cardiovascular system & hematology International Journal of Chronic Obstructive Pulmonary Disease medicine.disease Obstructive lung disease Pulmonary function testing 03 medical and health sciences FEV1/FVC ratio 0302 clinical medicine 030228 respiratory system DLCO Internal medicine Diffusing capacity medicine Cardiology medicine.symptom business |
| Zdroj: | International Journal of Chronic Obstructive Pulmonary Disease. |
| ISSN: | 1178-2005 |
| Popis: | Mehrdad Behnia,1 Courtney M Wheatley,2 Alberto Avolio,3 Bruce D Johnson2 1Division of Critical Care, Florida Hospital, Orlando, FL, 2Division of Cardiovascular Diseases, Mayo Clinic, Scottsdale, AZ, USA; 3Australian School of Advanced Medicine, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, NSW, Australia Background: Factors limiting exercise in patients with COPD are complex. With evidence for accelerated pulmonary vascular aging, destruction of alveolar–capillary bed, and hypoxic pulmonary vasoconstriction, the ability to functionally expand surface area during exercise may become a primary limitation.Purpose: To quantify measures of alveolar–capillary recruitment during exercise and the relationship to exercise capacity in a cohort of COPD patients.Methods: Thirty-two subjects gave consent (53% male, with mean ± standard deviation age 66±9 years, smoking 35±29 pack-years, and Global Initiative for Chronic Obstructive Lung Disease (GOLD) classification of 0–4: 2.3±0.8), filled out the St George’s Respiratory Questionnaire (SGRQ) to measure quality of life, had a complete blood count drawn, and underwent spirometry. The intrabreath (IB) technique for lung diffusing capacity for carbon monoxide (IBDLCO) and pulmonary blood flow (IBQc, at rest) was also performed. Subsequently, they completed a cycle ergometry test to exhaustion with measures of oxygen saturation and expired gases.Results: Baseline average measures were 44±21 for SGRQ score and 58±11 for FEV1/FVC. Peak oxygen consumption (VO2) was 11.4±3.1mL/kg/min (49% predicted). The mean resting IBDLCO was 9.7±5.4 mL/min/mmHg and IBQc was 4.7±0.9 L/min. At the first workload, heart rate (HR) increased to 92±11 bpm, VO2 was 8.3±1.4 mL/kg/min, and IBDLCO and IBQc increased by 46% and 43%, respectively, compared to resting values (p |
| Databáze: | OpenAIRE |
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