The Age-Related Rise of Plasma Cholesterol in Humans Is Not Caused by a Cell Removal Defect of LDL Particles: ‘In vitro’ Studies in Peripheral Mononuclear Blood Cells
| Autor: | Marisa Passarelli, Eder Carlos da Rocha Quintão, Edna Regina Nakandakare, Marcia Martins Silveira Bernik, M.D.T. Carvalho, M Q T S Neves |
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| Rok vydání: | 1997 |
| Předmět: |
Adult
Male Aging Very low-density lipoprotein medicine.medical_specialty Adolescent Apolipoprotein B Gene Expression In Vitro Techniques Peripheral blood mononuclear cell Blood cell chemistry.chemical_compound Internal medicine medicine Humans Carbon Radioisotopes Aged Apolipoproteins B biology Cholesterol Cholesterol LDL Metabolism Middle Aged In vitro Endocrinology medicine.anatomical_structure Receptors LDL chemistry Leukocytes Mononuclear biology.protein lipids (amino acids peptides and proteins) Geriatrics and Gerontology Lipoprotein |
| Zdroj: | Gerontology. 43:232-241 |
| ISSN: | 1423-0003 0304-324X |
| Popis: | In healthy subjects with a normal body mass index, total plasma cholesterol, low-density lipoprotein (LDL) cholesterol, and apoB lipoprotein levels are higher in older individuals (n = 34) than in younger subjects (n = 43). The two groups studied ranged in age from 60 to 93 years and from 17 to 30 years, respectively. The cholesterol synthesis rates of peripheral mononuclear blood cells from 14C-acetate, total and unesterified cholesterol concentrations in freshly isolated cells, and the rates of uptake of pooled donor LDL, labeled with 125I- or 14C-cholesteryl oleoyl ether, by cells derepressed in a lipoprotein-free medium were similar in both experimental groups. Thus, the rise of LDL cholesterol with age would seem to be likely secondary to the higher rate of very-low-density lipoprotein production, as shown by other investigators. |
| Databáze: | OpenAIRE |
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