D & C Yellow Nos. 10 and 11: delayed contact hypersensitivity in the guinea pig

Autor:	Salvatore J. De Salva, Susan A. Lamson, Betty Kong
Rok vydání:	1982
Předmět:	Ethanol Chemistry Stereochemistry Guinea Pigs Contact hypersensitivity Dermatology Dermatitis Contact Molecular biology Shampoo Guinea pig chemistry.chemical_compound medicine.anatomical_structure medicine Animals Immunology and Allergy Female Hypersensitivity Delayed Coloring Agents Sensitization
Zdroj:	Contact Dermatitis. 8:200-203
ISSN:	0105-1873
DOI:	10.1111/j.1600-0536.1982.tb04183.x
Popis:	D & C Yellow No. 11 was found to be a skin sensitizer in guinea pigs at an elicitation concentration of 10.0% in ethanol but not at 1.0 and 3.0%. Sensitization was induced with a 50% suspension in ethanol. D & C Yellow No. 10, the disodium salt of the mono- and disulfonic acids of D & C Yellow No. 11, was not a skin sensitizer nor was it capable of eliciting a response in the D & C Yellow No. 11-sensitized guinea pigs even at a challenge concentration of 10%. Two commercial products, a soap containing 0.015% D & C Yellow No. 11 and a shampoo containing 0.002% D & C Yellow No. 10 did not elicit a reaction in the D & C Yellow No. 11-sensitized guinea pigs.
Databáze:	OpenAIRE
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