Anti-gingivitis effect of a dentifrice containing bioactive glass (NovaMin) particulate
| Autor: | Zhuan Bian, Baojun Tai, Arthur E. Clark, David C. Greenspan, Han Jiang, Minquan Du, Jipin Zhong |
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| Rok vydání: | 2006 |
| Předmět: |
Adult
Male Toothbrushing Dental Plaque Dentistry Gingival Hemorrhage Biocompatible Materials Pilot Projects Dental plaque Placebo law.invention Placebos Gingivitis Randomized controlled trial Double-Blind Method law medicine Dentifrice Humans Dentifrices business.industry Calculus (dental) Dental Plaque Index medicine.disease Case-Control Studies Periodontics Female Glass medicine.symptom Periodontal Index business Follow-Up Studies |
| Zdroj: | Journal of clinical periodontology. 33(2) |
| ISSN: | 0303-6979 |
| Popis: | Background: The objective of this pilot clinical trial was to evaluate the anti-gingivitis and anti-plaque effects of a dentifrice containing bioactive glass (NovaMin®) compared with a placebo control dentifrice in a 6 weeks clinical study. Methods: The study design was a randomized, double-blinded, controlled clinical trial. One hundred volunteers took part in the study and were matched for plaque index (PLI), gingival bleeding index (GBI), age and gender. The protocol was reviewed and approved by the Ethical Committee of the University. The subjects received a supragingival prophylaxis to remove all plaque, calculus and extrinsic stain. Following the baseline examination, subjects were instructed to brush with their assigned dentifrice and toothbrush. The PLI and GBI were determined for the baseline and 6 weeks. The data were analysed using a repeated-measures ANOVA conducted on the two dependent measures to compare the effect between the test and control group. Results: Ninety-five subjects finished the study. The results showed that the PLI (baseline = 1.54, 6 weeks = 1.29) and GBI (baseline = 1.14, 6 weeks = 0.47) were significantly reduced, respectively, over the 6 weeks period in the test group (p |
| Databáze: | OpenAIRE |
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