Transient white matter changes on MR images in children undergoing chemotherapy for acute lymphocytic leukemia: correlation with neuropsychologic deficiencies
| Autor: | Don A. Wilson, M J Chaffin, C L Sexauer, M E Bowman, R Nitschke, J R Prince |
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| Rok vydání: | 1991 |
| Předmět: |
Male
medicine.medical_specialty Pediatrics Adolescent medicine.medical_treatment Neuropsychological Tests Sensitivity and Specificity White matter Predictive Value of Tests Acute lymphocytic leukemia Antineoplastic Combined Chemotherapy Protocols medicine Humans Radiology Nuclear Medicine and imaging Child Chemotherapy medicine.diagnostic_test business.industry Cognitive disorder Brain Infant Magnetic resonance imaging Precursor Cell Lymphoblastic Leukemia-Lymphoma medicine.disease Magnetic Resonance Imaging Surgery medicine.anatomical_structure El Niño Child Preschool Predictive value of tests Female sense organs business Complication |
| Zdroj: | Radiology. 180:205-209 |
| ISSN: | 1527-1315 0033-8419 |
| Popis: | The cranial magnetic resonance (MR) images of 25 children with acute lymphocytic leukemia (ALL) who were undergoing chemotherapy were retrospectively studied to determine the frequency of white matter changes and to analyze the significance of these observed changes in predicting subsequent neuropsychologic deficiencies. MR images showed transient white matter abnormalities in 17 of the 25 patients during consolidation therapy. Twelve of 20 children showed neuropsychologic deficits. There was no correlation between white matter changes and neuropsychologic deficits. In the subgroup of children under age 5 years at the time of diagnosis, 10 of 11 showed neuropsychologic deficits, and eight of 11 had white matter changes. Children under age 5 who undergo chemotherapy for ALL are at high risk to develop neuropsychologic deficiencies. Age at diagnosis is a reliable predictor of subsequent neuropsychologic deficits. |
| Databáze: | OpenAIRE |
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