Mycobacterium ulcerans Infection (Buruli Ulcer) in Southwest Nigeria
Autor: | Emmanuel Henry, O. P. Akinwale, Timothy Nwafor, Isaac Komolafe, P. V. Gyang, Adewale Oke |
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Jazyk: | angličtina |
Rok vydání: | 2020 |
Předmět: |
Buruli ulcer
index cases medicine.medical_specialty biology Buruli ulcer disease index cases endemic areas Mycobacterium ulcerans Southwest Nigeria business.industry lcsh:QR1-502 Pharmaceutical Science Buruli Ulcer Disease mycobacterium ulcerans medicine.disease biology.organism_classification southwest nigeria Dermatology lcsh:Microbiology Complementary and alternative medicine Health Care Sciences and Services Mycobacterium ulcerans medicine buruli ulcer disease Pharmacology (medical) endemic areas Sağlık Bilimleri ve Hizmetleri business |
Zdroj: | Journal of Microbiology and Infectious Diseases, Vol 10, Iss 02, Pp 82-88 (2020) Volume: 10, Issue: 02 82-88 Journal of Microbiology and Infectious Diseases |
ISSN: | 2146-9369 2146-3158 |
Popis: | Mycobacterium ulcerans Infection (Buruli Ulcer) in Southwest Nigeria Adewale Oke1, Isaac Komolafe1, Olaoluwa Akinwale2, Pam Gyang2, Emmanuel Henry2, Timothy Nwafor2 1Department of Biological Sciences, College of Natural Sciences, Redeemer’s University, Ede, Osun State, Nigeria 2Department of Public Health & Epidemiology, Nigerian Institute of Medical Research, 6, Edmund Crescent, Yaba, Lagos State, Nigeria ABSTRACT Objectives: Buruli Ulcer Disease (BUD) caused by Mycobacterium ulcerans is a severe neglected tropical disease of the skin, which has been reported in over 33 countries globally including Nigeria where the disease was first reported in 1967 and later in 1975. Since these reports, there has been no research on BU in the southwest Nigeria. In this study we assessed the presence of BUD in five states of the southwest Nigeria. Method: This was a community-based, cross-sectional study where BU awareness sessions preceded active search for suspected cases. Questionnaires were administered for participants' demography. Swab and fine needle aspirate specimens from suspected BU lesions were subjected to IS2404-based Nested PCR and Real time (qPCR) techniques to confirm BUD. Results: A total of 256 samples were collected and analyzed between April, 2016 and December, 2018. 157 (61.3%) samples were positive to IS2404 of M. ulcerans. Children below 15 years of age and adults constituted 42 cases (26.8%) and 115 cases (73.2%), respectively. Index BU cases were confirmed in Ekiti 4 (2.5%), Lagos 11 (7.3%), Ondo 16 (10.6%), Osun 61 (38.9%) and the remaining 64 (40.4%) were found in Ogun State. Ogun and Osun States accounted for 79.3% of all confirmed BU cases in this study. Conclusions: Conclusion: BU cases, for the first time, were confirmed in five states of SW Nigeria with two of them (Ogun and Osun States) indicating endemic situation, hence the need for those states to be kept under surveillance as potential BU flash points. On a larger scale, a robust BU awareness program nationwide should be embarked upon by the government and other stakeholders. J Microbiol Infect Dis 2020; 10(2):82-88. |
Databáze: | OpenAIRE |
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