Assessment of Gastrointestinal Symptoms and Non-transferrin Bound Iron After Oral Ferrous Sulfate and Iron-enriched Aspergillus Oryzae Supplementation in Women (P24-039-19)
| Autor: | Isaac Agbemafle, Richard F. Hurrell, Brian Wels, Manju B. Reddy, Chong Wang, Olivia Meier, Amanda E Bries |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Transferrin Saturation Measurement
chemistry.chemical_classification Nutrition and Dietetics Vitamins and Minerals biology medicine.medical_treatment Medicine (miscellaneous) Iron supplement biology.organism_classification medicine.disease Ferrous Microbiology chemistry.chemical_compound chemistry Aspergillus oryzae Iron-deficiency anemia Transferrin medicine Liver function Sulfate Food Science |
| Popis: | OBJECTIVES: Iron deficiency anemia (IDA) is a widespread nutritional deficiency. Iron supplementation with ferrous sulfate (FeSO4) is the most common strategy to treat IDA; however, the compliance with daily FeSO4 administration is poor, due to contraindicating side effects. Previously, we have reported that A. oryzae (Ultimine(®); ULT) is a novel iron source. Therefore, the objective of this study was to determine the biochemical assessment, non-transferrin bound iron (NTBI) and commonly related gastrointestinal side effects to assess the safety of A. oryzae compared to FeSO4. METHODS: Female participants (n = 16) with serum ferritin concentrations 40 µg/L were randomized to a double-blind, 9-wk cross-over study with a 3-wk placebo washout period between treatments. Oral iron supplements (65 mg Fe), FeSO(4) and ULT were administered for 21 consecutive days for each subject. Side effect questionnaires were collected 3d/wk over the 9-wk study period. Side effects and biochemical markers (nausea, heartburn, abdominal pain, fatigue, headache, diarrhea, constipation, oxidative stress and liver and kidney function) from iron supplementation were evaluated, along with serum iron, % transferrin saturation (TS) and NBTI 8 h curves. RESULTS: Serum iron, TS, and NTBI were all markedly higher with FeSO4 at each time-point from 2–8 hours (P |
| Databáze: | OpenAIRE |
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