Breastfeeding and the Risk of Childhood Hodgkin Lymphoma: A Systematic Review and Meta-analysis
| Autor: | Kelai Wang, Chun-Lan Liu, Hong-Yi Qu, Yan Zhuang |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Childhood Hodgkin Lymphoma
Cancer Research Pediatrics medicine.medical_specialty Epidemiology business.industry Public Health Environmental and Occupational Health Case-control study Breastfeeding Odds ratio Prognosis Hodgkin Disease Breast Feeding Meta-Analysis as Topic Oncology Risk Factors Case-Control Studies Relative risk Meta-analysis Humans Medicine Observational study Child business |
| Zdroj: | Asian Pacific Journal of Cancer Prevention. 14:4733-4737 |
| ISSN: | 1513-7368 |
| DOI: | 10.7314/apjcp.2013.14.8.4733 |
| Popis: | Purpose: Numerous observational epidemiological studies have evaluated associations between breastfeeding and the risk of childhood Hodgkin lymphoma; however, the existing results are inconsistent. We therefore conducted a systematic review and meta-analysis. Methods: Medical literature was searched in the Pubmed and Embase databases to identify all English-language relevant studies up to April 10, 2013. Reference lists were thereafter hand-searched for additional articles. Studies that reported relative risk ratios (RRs) or odds ratios (ORs) with 95% confidence intervals (CIs) were included. This meta-analysis was conducted in accordance with the guidelines for the meta-analysis of observational studies in epidemiology. Results: We finally included 10 case-control studies in our meta-analysis, involving 1,618 childhood Hodgkin lymphoma cases and 8,181 controls. Overall, we did found a borderline significant association between breastfeeding and reduced risk of childhood Hodgkin lymphoma comparing ever breastfed children to never breastfed children (pooled OR =0.79; 95%CI, 0.58-1.08; P=0.13), with limited evidence for between-study heterogeneity (P =0.12, I 2 = 35.70%). Conclusion: There is limited evidence for an inverse association between breastfeeding and risk of childhood Hodgkin lymphoma. |
| Databáze: | OpenAIRE |
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