Acetylcholinesterase inhibitors: novel activities of old molecules
| Autor: | Michela Mazzucchelli, Stefano Govoni, Cristina Lanni, Marco Racchi, Emanuela Porrello |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Pharmacology
Amyloid beta-Protein Precursor chemistry.chemical_compound Cognition Alzheimer Disease mental disorders medicine Galantamine Amyloid precursor protein Humans Donepezil Rivastigmine biology business.industry Acetylcholinesterase Neuroprotective Agents chemistry Tacrine biology.protein Cholinergic Cholinesterase Inhibitors business Amyloid precursor protein secretase Neuroscience medicine.drug |
| Zdroj: | Pharmacological Research. 50:441-451 |
| ISSN: | 1043-6618 |
| Popis: | The therapeutic approach for improving the cognitive function in patients with Alzheimer's disease (AD) is mainly based on the potentiation of central cholinergic activity and is achieved clinically by the use of acetylcholinesterase (AChE) inhibitors such as tacrine, donepezil, rivastigmine, galantamine and other drugs currently in clinical trials. These are, by their pharmacology, only symptomatic drugs yet recently these molecules have shown some potential also in the modulation of amyloid precursor protein (APP) processing. We explore in this review the experimental evidence that suggests a role for AChEIs in APP processing and point to multiple complex mechanisms involving either a cholinergic agonist effect, coupled to multiple signal transduction pathways, or post-transcriptional effects that modulate the expression of cellular APP. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect