Three-micrometer-diameter needle electrode with an amplifier for extracellular in vivo recordings
| Autor: | Xian Long Angela Leong, Koji Yamashita, Yu Seikoba, Shota Yamagiwa, Kowa Koida, Shinnosuke Idogawa, Shuhei Tsuruhara, Hiroshi Kubo, Hirohito Sawahata, Takeshi Kawano, Rika Numano, Yuto Kita |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
Materials science Action Potentials 02 engineering and technology Local field potential Signal-To-Noise Ratio Signal Micrometre 03 medical and health sciences Mice Stack (abstract data type) Electric Impedance Animals Electrical impedance Microscale chemistry 030304 developmental biology Neurons 0303 health sciences Multidisciplinary Amplifier Brain Electroencephalography Equipment Design 021001 nanoscience & nanotechnology Electrodes Implanted Electrophysiology Microelectrode Physical Sciences 0210 nano-technology Microelectrodes Biomedical engineering |
| Zdroj: | Proc Natl Acad Sci U S A |
| Popis: | Microscale needle-electrode devices offer neuronal signal recording capability in brain tissue; however, using needles of smaller geometry to minimize tissue damage causes degradation of electrical properties, including high electrical impedance and low signal-to-noise ratio (SNR) recording. We overcome these limitations using a device assembly technique that uses a single needle-topped amplifier package, called STACK, within a device of ∼1 × 1 mm(2). Based on silicon (Si) growth technology, a 0.98 (−0.175 dB), enabling recording of the local field potential and action potentials from the mouse brain in vivo with an improved SNR of 6.2. Additionally, the device allowed us to use a Bluetooth module to demonstrate wireless recording of these neuronal signals; the chronic experiment was also conducted using STACK-implanted mice. |
| Databáze: | OpenAIRE |
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