The effect of oral contraceptives on rat platelet membrane glycoproteins
| Autor: | Bina Toor, Serge Renaud, Lilian McGregor, John L. McGregor, Kenneth J. Clemetson |
|---|---|
| Rok vydání: | 1984 |
| Předmět: |
Blood Platelets
Wheat Germ Agglutinins Biophysics Biology Platelet membrane glycoprotein Biochemistry Contraceptives Oral Hormonal chemistry.chemical_compound Oral administration Lectins Animals Platelet Glycoproteins chemistry.chemical_classification Binding Sites Ligand binding assay Cell Membrane Granule (cell biology) Rats Inbred Strains Cell Biology Wheat germ agglutinin Rats Sialic acid chemistry Sialic Acids Female Glycoprotein Contraceptives Oral |
| Zdroj: | Biochimica et Biophysica Acta (BBA) - Biomembranes. 770:178-182 |
| ISSN: | 0005-2736 |
| DOI: | 10.1016/0005-2736(84)90128-7 |
| Popis: | Female rats were administered oral contraceptives and the levels of sialic acid on platelet membrane and granule glycoproteins were compared to controls using a sialic acid assay and a fluorescein-conjugated wheat germ agglutinin binding assay and also by measuring the binding of 125I-labelled wheat germ agglutinin to glycoprotein bands from platelets separated by polyacrylamide electrophoresis. The contraceptive-treated rats showed increased levels of glycoprotein sialylation which may partly explain the altered physiological function of the platelets. |
| Databáze: | OpenAIRE |
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