Hepatitis C virus cascade of care in the general population, in people with diabetes, and in substance use disorder patients

Autor:	Valeria Manicardi, Giorgia Collini, Marta Ottone, Paolo Giorgi Rossi, Alessandro Zerbini, Pamela Mancuso, Massimo Vicentini, Antonio Nicolaci, Olivera Djuric, Marco Massari, Loreta A. Kondili, Angela Zannini
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	Cancer Research medicine.medical_specialty Cascade of care Epidemiology Hepatocellular carcinoma Hepatitis C virus Population Addiction medicine.disease_cause lcsh:RC254-282 HCV Positive lcsh:Infectious and parasitic diseases 03 medical and health sciences 0302 clinical medicine Linkage to care Diabetes mellitus Internal medicine medicine lcsh:RC109-216 030212 general & internal medicine education education.field_of_study business.industry medicine.disease lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens Northern italy Substance abuse Infectious Diseases Oncology Tropical medicine 030211 gastroenterology & hepatology business Research Article
Zdroj:	Infectious Agents and Cancer, Vol 16, Iss 1, Pp 1-11 (2021) Infectious Agents and Cancer
ISSN:	1750-9378
Popis:	Background The aim was to evaluate the hepatitis C virus (HCV) cascade of care in the general population (GP) and in two high-risk populations: patients with diabetes mellitus (DM) and substance users (AS) in treatment in Reggio Emilia Province, Italy. Methods A population-based cross-sectional study was conducted that included 534,476 residents of the Reggio Emilia Province, of whom 32,800 were DM patients and 2726 AS patients. Age-adjusted prevalence was calculated using the direct method of adjustment based on the age-specific structure of EU population. Results The prevalence of HCV testing was 11.5%, 13.8%, and 47.8% in GP, DM, and AS patients respectively, while HCV prevalence was 6.5/1000, 12.6/1000, and 167/1000, respectively. The prevalence of HCV RNA positivity was 4.4/1000, 8.7/1000, and 114/1000 in the three populations, respectively. The rates of HCV RNA-positive individuals not linked to care were 27.9%, 27.3%, and 26% in GP, DM, and AS patients, respectively, while the rates of those cured or cleared were 70.9%, 71%, and 69.9%, respectively. The prevalence of HCV testing was higher for females of reproductive age than for males the same age: 218.4/1000 vs. 74.0/1000, respectively. While more foreigners than Italians underwent the HCV test and were HCV positive, fewer foreigners than Italians received HCV treatment and were cured. Conclusions The low HCV testing and linkage to care rates remain an important gap in the HCV cascade of care in Northern Italy. The prevalence of cured/cleared residents remains lower among foreigners than among Italians.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5195fd6319de82809d8f9322326cb0ab https://doaj.org/article/93e30d5e345a4311978ee9031db167e9 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.