The relation between pantothenic acid and Plasmodium gallinaceum infections in the chicken and the antimalarial activity of analogues of pantothenic acid
| Autor: | Emanuel Waletzky, Margaret Baker, Sterling Brackett |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Vitamin
Malaria Avian Plasmodium gallinaceum Pantoyltaurine Biology Pantothenic Acid chemistry.chemical_compound Antimalarials In vivo Pantothenic acid medicine Animals Humans Ecology Evolution Behavior and Systematics Quinine Metabolism Vitamins biology.organism_classification Virology In vitro Malaria Biochemistry chemistry Vitamin B Complex Parasitology Chickens medicine.drug |
| Zdroj: | The Journal of parasitology. 32(5) |
| ISSN: | 0022-3395 |
| Popis: | There is common agreement on the desirability of developing new chemotherapeutic agents on a less empirical basis than that of testing miscellaneous compounds, but such an attempt is handicapped by inadequate knowledge of the metabolism of pathogenic organisms. The possibilities of other approaches are illustrated by the results of McIlwain and Hawking (1943) who showed that hemolytic streptococci which are known to require pantothenic acid for growth are inhibited in development both in vitro and in vivo by pantoyltaurine, an analogue of pantothenic acid. It was believed that if the nutritional requirements of Plasmodium gallinaceum were known, such information might be useful as a guide in the selection and synthesis of compounds to be tested as antimalarials. No satisfactory procedure for the in vitro cultivation of P. gallinaceum was available when this work began (Ball, et al, 1945) therefore, an investigation of its nutritional requirements was limited by the fact that in vivo cultivation must be used. A study of the pantothenic acid requirements of this parasite was chosen since the requirements of the host for this vitamin are well known (Jukes and McElroy, 1943) and since Mcllwain's data showed that analogues of pantothenic acid may have chemotherapeutic activity. |
| Databáze: | OpenAIRE |
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