Preclinical study of a novel hydrodynamically levitated centrifugal pump for long-term cardiopulmonary support
| Autor: | Tomonori Tsukiya, Yoshiyuki Taenaka, Eisuke Tatsumi, Yoshiaki Takewa, Toshihide Mizuno |
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| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment Biomedical Engineering Medicine (miscellaneous) Hemodynamics Extracorporeal Biomaterials Extracorporeal Membrane Oxygenation Materials Testing medicine Extracorporeal membrane oxygenation Animals Thrombus Oxygenators Membrane business.industry Goats Equipment Design medicine.disease Centrifugal pump Cardiac surgery Surgery Blood pump Anesthesia Hydrodynamics Venae cavae Cardiology and Cardiovascular Medicine business |
| Zdroj: | Journal of Artificial Organs. 18:300-306 |
| ISSN: | 1619-0904 1434-7229 |
| Popis: | An extracorporeal centrifugal blood pump with a hydrodynamically levitated impeller was developed for use in a durable extracorporeal membrane oxygenation (ECMO) system. The present study examined the biocompatibility of the blood pump during long-term use by conducting a series of 30-day chronic animal experiments. The ECMO system was used to produce a percutaneous venoarterial bypass between the venae cavae and carotid artery in adult goats. No anticoagulation or antiplatelet therapy was administered during the experiments. Three out of four animals survived for the scheduled 30-day period, and the blood pumps and membrane oxygenators both exhibited sufficient hydrodynamic performance and good antithrombogenicity, while one animal died of massive bleeding from the outflow cannulation site. The animals' plasma free hemoglobin had returned to within the normal range by 1 week after the surgical intervention, and their hemodynamic and biochemistry parameters remained within their normal ranges throughout the experiment. The explanted centrifugal blood pumps did not display any trace of thrombus formation. Based on the biocompatibility demonstrated in this study, the examined centrifugal blood pump, which includes a hydrodynamically levitated impeller, is suitable for use in durable ECMO systems. |
| Databáze: | OpenAIRE |
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