Role of Snai2 and Notch signaling in salivary gland myoepithelial cell fate

Autor:	Rika Yasuhara, Seya Kang, Tarou Irié, Yo Mabuchi, Satoko Kujiraoka, Akane Yukimori, Shoko Ishida, Junichi Tanaka, Kenji Mishima
Rok vydání:	2022
Předmět:	Mice Myosin Heavy Chains Animals Epithelial Cells Muscle Smooth Cell Biology Integrin alpha6 Epithelial Cell Adhesion Molecule Molecular Biology Actins Salivary Glands Biomarkers Pathology and Forensic Medicine
Zdroj:	Laboratory Investigation. 102:1245-1256
ISSN:	0023-6837
Popis:	Myoepithelial (ME) cells in exocrine glands exhibit both epithelial and mesenchymal features, contributing to fluid secretion through contraction. However, the regulation mechanism of behind this unique phenotype in salivary glands remains unclear. We established a flow cytometry-based purification method using cell surface molecules, epithelial cell adhesion molecule (EpCAM) and alpha 6 integrin (CD49f), to characterize ME cells. EpCAM
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::519255e442f5a269cd30995f79764a39 https://doi.org/10.1038/s41374-022-00814-7 Zobrazit plný text záznamu Full text from SpringerLink