Lymphangitic Retroperitoneal Carcinomatosis Occurring From Metastatic Sarcomatoid Chromophobe Renal Cell Carcinoma
| Autor: | Meghna Alimchandani, Maria Tsokos, Maria J. Merino, W. M. Linehan, Karlena Lara |
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| Rok vydání: | 2014 |
| Předmět: |
Lymph node metastasis
Pathology medicine.medical_specialty Chromophobe Proliferation index business.industry Urology medicine.medical_treatment Chromophobe Renal Cell Carcinoma Chromophobe cell lcsh:Diseases of the genitourinary system. Urology lcsh:RC870-923 medicine.disease Renal cell carcinoma Sarcomatoid Nephrectomy Cytokeratin Lymphatic system Oncology Lymphangitic Carcinomatosis Lymphangitic carcinomatosis medicine business |
| Zdroj: | Urology Case Reports Urology Case Reports, Vol 2, Iss 2, Pp 39-42 (2014) |
| ISSN: | 2214-4420 |
| DOI: | 10.1016/j.eucr.2013.12.008 |
| Popis: | A 45-year-old man with left renal mass underwent nephrectomy to reveal a 20-cm tumor diagnosed as sarcomatoid chromophobe renal cell carcinoma. Lymph node metastasis of chromophobe and sarcomatoid components, disseminated tumor in retroperitoneal fat, lymphatic vessels, and perirenal adipose tissue in lymphangitic carcinomatosis pattern were identified. Chromophobe epithelial cells were positive for epithelial membrane antigen, c-Kit, and cytokeratin 7; sarcomatoid cells were positive for CD10 and smooth muscle antigen with high proliferation index. Chromophobe epithelial cells had loss of heterozygosity in chromosomes 1p and 1q, whereas sarcomatoid cells had loss of heterozygosity in 3p, 1p, and 1q. In conclusion, sarcomatoid chromophobe renal cell carcinoma has aggressive biologic behavior and potential to metastasize in unusual patterns. Keywords: Renal cell carcinoma, Chromophobe, Sarcomatoid, Lymphangitic carcinomatosis, Lymph node metastasis |
| Databáze: | OpenAIRE |
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