Lactate biosensing: The emerging point-of-care and personal health monitoring
| Autor: | Fahmida Alam, Naznin Akter, Nezih Pala, Ahmed Hasnain Jalal, Yogeswaran Umasankar, Shekhar Bhansali, Sohini RoyChoudhury, Shahrzad Forouzanfar |
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| Rok vydání: | 2018 |
| Předmět: |
Point-of-Care Systems
Biomedical Engineering Biophysics 02 engineering and technology Personal health monitoring Biosensing Techniques 01 natural sciences Mixed Function Oxygenases chemistry.chemical_compound Lactate dehydrogenase Electrochemistry Medicine Animals Humans Lactic Acid Precision Medicine Point of care Fluorescent Dyes Photons Molecular Structure business.industry 010401 analytical chemistry General Medicine Electrochemical Techniques 021001 nanoscience & nanotechnology Oxygen deficit Photochemical Processes 0104 chemical sciences chemistry Tears Lactate oxidase 0210 nano-technology business Anaerobic exercise Biosensor Biotechnology Biomedical engineering |
| Zdroj: | Biosensorsbioelectronics. 117 |
| ISSN: | 1873-4235 |
| Popis: | Lactate plays a crucial role in the anaerobic metabolic pathway of humans. In situations of oxygen deficit, its production increases; leading to several life-threatening conditions such as hemorrhage, respiratory failure, trauma or ischemia from lactate acidosis. Lactate level detection and point-of-care (POC) monitoring in a fast, accurate and non-invasive manner is ultimately important for many health care applications. Optical and electrochemical techniques are employed in lactate sensing to achieve high sensitivity and selectivity, miniaturization, portability, simplicity, and low cost. To improve the selectivity and sensitivity, two important enzymes, lactate oxidase (LOx) and lactate dehydrogenese (LDH) are employed. Conventional methods for lactate detection are not fast enough to be used in point-of-care or personal health monitoring settings. Moreover, the existing point-of-care lactate sensing tools follow invasive or partially invasive sampling protocols such as finger pricking. In this review, a comprehensive overview of different lactate biosensing devices is presented. Particularly, the state-of-the-art and prospects of wearable, non-invasive lactate sensing from different biofluids are discussed. |
| Databáze: | OpenAIRE |
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