Nuclear Translocation of β-Catenin Protein but Absence of β-Catenin and APC Mutation in Gastrointestinal Carcinoid Tumor
| Autor: | Hsin-Lien Kao, Min-Cheng Su, Yung-Ming Jeng, Ray-Hwang Yuan, Ting-Huang Wang, Chun-Chin Chen, Rey-Heng Hu, Chia-Chi Wang |
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| Rok vydání: | 2006 |
| Předmět: |
Cytoplasm
Pathology medicine.medical_specialty Carcinoid tumors Adenomatous Polyposis Coli Protein Carcinoid Tumor Gene mutation Neuroendocrine differentiation Exon Surgical oncology Humans Medicine neoplasms beta Catenin Gastrointestinal Neoplasms Cell Nucleus Gastrointestinal tract business.industry Wnt signaling pathway Exons medicine.disease digestive system diseases Protein Transport Oncology Catenin Mutation Cancer research Surgery business Subcellular Fractions |
| Zdroj: | Annals of Surgical Oncology. 13:1604-1609 |
| ISSN: | 1534-4681 1068-9265 |
| DOI: | 10.1245/s10434-006-9072-2 |
| Popis: | Carcinoid tumors are a group of heterogeneous tumors with neuroendocrine differentiation and are mainly located in the gastrointestinal tract. A high frequency of cytoplasmic accumulation and/or nuclear translocation of beta-catenin with frequent mutations of exon 3 of beta-catenin gene in gastrointestinal carcinoid tumor has been previously described, but the role of Wnt/beta-catenin/APC pathway in the genesis of carcinoid tumor remains largely unknown.To further characterize the role of Wnt/beta-catenin/APC pathway, we investigated 91 gastrointestinal carcinoid tumors and, for comparison, 26 extragastrointestinal carcinoid tumors by immunohistochemical detection of beta-catenin protein and direct sequencing of exon 3 of the beta-catenin gene and exon 15 of the APC gene.Cytoplasmic accumulation and/or nuclear translocation of beta-catenin were found in 27 gastrointestinal carcinoid tumors (29.7%) but not in any extragastrointestinal carcinoid tumors. Interestingly, neither beta-catenin nor APC gene mutation was detected in all of the cases with nuclear expression of beta-catenin.Our results indicate that the role beta-catenin plays in the genesis of gastrointestinal and extragastrointestinal carcinoid tumors is different. Nuclear expression of beta-catenin does not occur in extragastrointestinal carcinoid tumors, and mutation of exon 3 of beta-catenin gene and exon 15 of APC gene does not contribute to the activation of Wnt/beta-catenin/APC pathway in gastrointestinal carcinoid tumors. |
| Databáze: | OpenAIRE |
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