NRGN, S100B and GFAP levels are significantly increased in patients with structural lesions resulting from mild traumatic brain injuries

Autor: Celaleddin Soyalp, Enes Akkaya, Mustafa Murat Özgenç, Sevket Evran, Fatih Çalış, Hakan Hanimoglu, Serdar Çevik, Ahmet Güneyk, Salim Katar, Mehmet Yasar Kaynar
Přispěvatelé: Tıp Fakültesi
Rok vydání: 2018
Předmět:
Adult
Male
Traumatic Brain Injury
Adolescent
Traumatic brain injury
Nausea
Amnesia
S100 Calcium Binding Protein beta Subunit
Sensitivity and Specificity
03 medical and health sciences
0302 clinical medicine
Computed Tomography
Glial Fibrillary Acidic Protein
medicine
Humans
Neurogranin
Child
Brain Concussion
Glial fibrillary acidic protein
biology
business.industry
Glasgow Coma Scale
General Medicine
Emergency department
Middle Aged
medicine.disease
Cevik S.
Ozgenc M. M.
Guneyk A.
Evran S.
Akkaya E.
Calis F.
Katar S.
Soyalp C.
Hanimoglu H.
Kaynar M. Y.
-NRGN
S100B and GFAP levels are significantly increased in patients with structural lesions resulting from mild traumatic brain injuries-
CLINICAL NEUROLOGY AND NEUROSURGERY
cilt.183
2019
030220 oncology & carcinogenesis
Anesthesia
Brain Injuries
Neurogranin
Calcium-Binding Protein S100 Beta
biology.protein
Vomiting
Surgery
Female
Neurology (clinical)
medicine.symptom
business
030217 neurology & neurosurgery
Biomarkers
Zdroj: Clinical neurology and neurosurgery. 183
ISSN: 1872-6968
Popis: Objective: To determine whether serum neurogranin (NRGN), glial fibrillary acidic protein (GFAP), and calciumbinding protein S100 beta (S100B) levels are associated with traumatic intracranial lesions compared to computed tomography (CT) findings of patients with mild traumatic brain injury (mTBI). Patients and Methods: The cross-sectional study cohort included 48 patients who were admitted to the Emergency Department with a complaint of mTBI, a Glasgow Coma Scale score of 14–15, and at least one symptom of head trauma (i.e., post-traumatic amnesia, nausea or vomiting, post-traumatic seizures, persistent headache, and transient loss of consciousness). Blood samples and CT scans were obtained for all patients within 4 h of injury. Age-matched patients without intracranial traumatic pathology (CT-) were recruited as a control group. Blood samples were measured for NRGN, GFAP, and S100B levels. Results: Of 48 patients, 24 were CT + and had significantly higher serum NRGN (5.79 vs. 2.95 ng/mL), GFAP (0.59 vs.0.36 ng/mL), and S100B (1.72 vs.0.73 μg/L) levels than those who were CT- (p = 0.001, p = 0.026, and p < 0.001, respectively). ROC curves showed that NRGN, GFAP, and S100B levels were sufficient to distinguish traumatic brain injury in patients with mTBI. At the cut-off value for NRGN of 1.87 ng/mL, sensivity was 83.3%, and specificity was 58.3%. At the cut-off value for GFAP of 0.23 ng/mL, sensivity was 75% and specificity was 62.5%. The optimal cut-off value for S100B was 0.47 μg/L (95.8% sensitivity and 62.5% specificity). Conclusion: This is the first study to evaluate NRGN in human serum after mTBI. We confirmed that NRGN levels were significantly higher in CT + patients than CT- patients in the mTBI patient population. Future studies of larger populations and different age groups (especially pediatric) can help reduce the number of CT scans as a reliable and noninvasive diagnostic tool for evaluating NRGN protein levels in mTBI patients with a low probability of intracranial lesions.
Databáze: OpenAIRE
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