CAR T cell therapy: inroads to response and resistance
| Autor: | Christine E. Brown, Crystal L. Mackall |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
History Lymphoma T-Lymphocytes medicine.medical_treatment Receptors Antigen T-Cell Immunotherapy Adoptive Education 03 medical and health sciences 0302 clinical medicine Antigen medicine Humans Receptor T cell immunotherapy B cell Leukemia business.industry Immunotherapy medicine.disease Chimeric antigen receptor Computer Science Applications 030104 developmental biology medicine.anatomical_structure Cancer research CAR T-cell therapy business 030215 immunology |
| Zdroj: | Nature Reviews Immunology. 19:73-74 |
| ISSN: | 1474-1741 1474-1733 |
| Popis: | Here, we highlight key papers published in 2018 that advance our understanding of resistance to chimeric antigen receptor (CAR) T cell immunotherapy for leukaemia and lymphoma and in so doing reveal barriers that must be addressed to increase efficacy of this novel class of therapeutics for B cell malignancies and expand their reach to solid tumours. Several clinical studies in 2018 documented the potency of therapies based on T cells with chimeric antigen receptors (CAR T cells), but also revealed mechanisms of resistance. These insights may facilitate the design of improved CAR T cell therapies for B cell malignancies and beyond. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink