Gastric cancer incidence in the Romagna Region of Italy: A spatial and temporal analysis
| Autor: | Orietta Giuliani, Lauro Bucchi, Stefania Giorgetti, Fabio Falcini, Americo Colamartini, Silvia Mancini, Alessandra Ravaioli |
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| Rok vydání: | 2015 |
| Předmět: |
Male
medicine.medical_specialty Younger people Rate ratio Spatio-Temporal Analysis Risk Factors Stomach Neoplasms medicine Humans Registries Aged Aged 80 and over Hepatology business.industry Incidence Incidence (epidemiology) Gastroenterology Spatial epidemiology Middle Aged Confidence interval Northern italy Surgery Italy Cancer incidence Relative risk Female business Demography |
| Zdroj: | Digestive and Liver Disease. 47:1076-1081 |
| ISSN: | 1590-8658 |
| Popis: | Background The worldwide decrease in gastric cancer incidence is due to a birth-cohort-dependent decrease in exposure to major risk factors. Methods In an area of northern Italy with a historically strong internal geographical gradient in gastric cancer incidence, variations in rates by municipality and age group between 1987 and 2008 were evaluated. The study period was divided into three nonadjacent periods. End points included: age- and sex-standardised incidence rates; incidence rate ratio between age- and sex-standardised incidence rates; smoothed relative risks of gastric cancer incidence, and posterior probabilities of the relative risk being >1. Results In 1987–1990, the estimate of posterior probabilities of relative risk being >1 showed a higher incidence in hilly/mountainous areas. Between 1987–1990 and 2005–2008, a uniform decrease of more than 50% was observed (incidence rate ratio: plain, 0.45 (95% confidence interval 0.40–0.51); hill, 0.44 (0.34–0.58); mountain, 0.48 (0.22–1.02)). The decrease in the mountainous area was weak in the middle time period, with an incidence rate ratio of 0.92 (0.46–1.84), and intensified afterwards. The decrease occurred earlier and was more pronounced among younger people. In 2005–2008, gastric cancer risk was uniform across ages and municipalities. Conclusions The observed changes in gastric cancer incidence is the epilogue of a birth-cohort-dependent decrease in exposure to major risk factors. |
| Databáze: | OpenAIRE |
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