Iron deficiency increases blood manganese level in the Korean general population according to KNHANES 2008
| Autor: | Byung Kook Lee, Yangho Kim |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Adult
Male Gerontology Anemia Population Toxicology Young Adult Republic of Korea medicine Humans Young adult education Aged National health Manganese education.field_of_study Anemia Iron-Deficiency biology business.industry General Neuroscience Iron deficiency Middle Aged medicine.disease Health Surveys Ferritin Iron-deficiency anemia Blood manganese level biology.protein Female business Biomarkers Demography |
| Zdroj: | NeuroToxicology. 32:247-254 |
| ISSN: | 0161-813X |
| DOI: | 10.1016/j.neuro.2010.12.006 |
| Popis: | s Introduction We present data from Korean National Health and Nutritional Examination Survey (KNHANES) 2008 on the distribution of blood manganese (Mn) levels and their associations with iron deficiency in a representative sample of the adult Korean population. Methods This study was based on data obtained in KNHANES 2008, which was conducted for three years (2007–2009) using a rolling sampling design that involves a complex, stratified, multistage, probability-cluster survey of a representative sample of the noninstitutionalized civilian population in South Korea. Results Geometric means (GMs) of blood Mn in the low serum ferritin group in women, men, and all participants were significantly higher than in the normal group. GMs of blood Mn in the low-normal serum ferritin groups in women and all participants were significantly higher than in the normal group. In addition, multiple regression analysis after controlling for covariates including gender, age, regional area, education level, and smoking and drinking status showed that blood Mn was significantly higher in the low ferritin group in women, men, and all participants compared with the normal group, whereas blood Mn was significantly higher in the low-normal ferritin group only in women and all participants. Discussion The present study shows that iron deficiency increases blood Mn level in the general population. To the best of our knowledge, the present study is the first to show an association between blood Mn level and ferritin level in a representative sample of the adult population such as that evaluated in KNHANES. |
| Databáze: | OpenAIRE |
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