Association between exposure to polycyclic aromatic hydrocarbons and brain cortical thinning: The Environmental Pollution-Induced Neurological EFfects (EPINEF) study
Autor: | Young Noh, Ho Hyun Kim, Jaelim Cho, Sang Baek Koh, Woojin Kim, Juhwan Noh, Seong Kyung Cho, Hee Jin Kim, Sung Soo Oh, Dae Seock Shin, Hwasun Seo, Gayoung Seo, Jungwoo Sohn, Seung Koo Lee, Sang Won Seo, Jung Il Lee, Seongho Seo, Nak-Young Kim, Sun Young Kim, Changsoo Kim, Heeseon Jang |
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Rok vydání: | 2019 |
Předmět: |
Adult
Male Environmental Engineering 010504 meteorology & atmospheric sciences Urinary system Physiology Cortical thinning Environmental pollution 010501 environmental sciences Verbal learning 01 natural sciences Neuroimaging Republic of Korea medicine Environmental Chemistry Humans Polycyclic Aromatic Hydrocarbons Child Waste Management and Disposal 0105 earth and related environmental sciences business.industry Neurotoxicity Neuropsychology Brain Environmental Exposure medicine.disease Pollution Quartile Female business Environmental Pollution Biomarkers |
Zdroj: | The Science of the total environment. 737 |
ISSN: | 1879-1026 |
Popis: | Although some studies have suggested that exposure to polycyclic aromatic hydrocarbons (PAHs) induces neurodevelopmental disturbances in children and neurodegeneration in animals, the neurotoxic effect of PAH exposure is unclear in adults. The aim was to examine the associations of PAH exposure with brain structure and neuropsychological function in adults without known neurological diseases.This study included 421 men and 528 women dwelling in four cities in the Republic of Korea. Urinary concentrations of four PAH metabolites (1-hydroxypyrene, 2-naphthol, 1-hydroxyphenanthrene, and 2-hydroxyfluorene) were obtained. Participants underwent brain 3 T magnetic resonance imaging and neuropsychological tests. Cortical thickness and volume were estimated using the region-of-interest method. Separate generalized linear models were constructed for each sex, adjusting for age, years of education, cohabitation status, income, tobacco use, alcohol consumption, and vascular risk factors.The mean (standard deviation) age was 68.3 (6.6) years in men and 66.4 (6.1) years in women. In men, those in quartile 4 (versus quartile 1, the lowest) of urinary 2-naphthol concentration had cortical thinning in the global (β = -0.03, P = .02), parietal (β = -0.04, P = .01), temporal (β = -0.06, P .001), and insular lobes (β = -0.05, P = .02). Higher quartiles of urinary 2-naphthol concentration were associated with cortical thinning in the global (P = .01), parietal (P = .004), temporal (P .001), and insular lobes (P = .01). In women, those in quartile 4 (versus quartile 1) of urinary 1-hydroxypyrene concentration had cortical thinning in the frontal (β = -0.03, P = .006) and parietal lobes (β = -0.03, P = .003). Higher quartiles of urinary 1-hydroxypyrene concentration were associated with cortical thinning in the frontal (P = .006) and parietal lobes (P = .001). In both sexes, verbal learning and memory scores significantly declined with an increase in quartile of urinary 1-hydroxypyrene concentration.PAH exposure was associated with cortical thinning and decline in verbal learning and memory function in cognitively healthy adults. This suggests PAHs as an environmental risk factor for neurodegeneration. |
Databáze: | OpenAIRE |
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