Comparison of human papillomavirus (HPV) detection in urine and cervical swab samples using the HPV GenoArray Diagnostic assay
| Autor: | Pairoj Junyangdikul, Anant Karalak, Pornjarim Nilyanimit, Yong Poovorawan, Piyawat Laowahutanont, Jira Chansaenroj |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
HPV Genotyping medicine.medical_specialty Concordance 030106 microbiology lcsh:Medicine Women’s Health Urine Hpv detection General Biochemistry Genetics and Molecular Biology 03 medical and health sciences 0302 clinical medicine Virology Medicine Human papillomavirus Cervical cancer business.industry Obstetrics General Neuroscience lcsh:R virus diseases General Medicine medicine.disease female genital diseases and pregnancy complications Hpv testing Infectious Diseases Oncology 030220 oncology & carcinogenesis Cervical swab General Agricultural and Biological Sciences business |
| Zdroj: | PeerJ PeerJ, Vol 5, p e3910 (2017) |
| ISSN: | 2167-8359 |
| DOI: | 10.7717/peerj.3910 |
| Popis: | Human papillomavirus (HPV) is the leading cause of cervical cancer. Urine-based HPV testing offers a simple and non-invasive method because of its increasing acceptance. A total of 164 pairs of cervical swab and urine samples from Thai women who underwent cervical cancer screening were used for HPV testing with HPV GenoArray Diagnostic Kits. The overall concordance percentage for HPV detection in the cervical swab and urine samples was 65.2%. The HPV genotypes most commonly detected were HPV16 and HPV18. An analysis of the urine samples and a second analysis of the cervical swab samples showed that the differences in the overall HPV detection rate between women with normal and abnormal cytology were not significant (p > 0.05). Urine samples processed with the GenoArray assay is an alternative for women who decline to undergo Pap smear even though it is not ideal as the first-line screening option. |
| Databáze: | OpenAIRE |
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