Cardiovascular Effects of Pioglitazone or Sulfonylureas According to Pretreatment Risk: Moving Toward Personalized Care
| Autor: | Giuseppe Lucisano, Olga Vaccaro, Sebastiano Squatrito, Maria Masulli, Carlo Giorda, Aldo P. Maggioni, Paolo Mocarelli, Antonio Nicolucci, Enzo Bonora, Gabriele Riccardi, Stefano Del Prato, Tosca.It Investigators, Angela A. Rivellese |
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| Přispěvatelé: | Vaccaro, O., Lucisano, G., Masulli, M., Bonora, E., Del Prato, S., Rivellese, A. A., Giorda, C. B., Mocarelli, P., Squatrito, S., Maggioni, A. P., Riccardi, G., Nicolucci, A. |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
Endocrinology Diabetes and Metabolism Clinical Biochemistry Type 2 diabetes 030204 cardiovascular system & hematology Lower risk Biochemistry 03 medical and health sciences Hypoglycemic drug type 2 diabetes CV disease 0302 clinical medicine Endocrinology Insulin resistance Internal medicine Diabetes mellitus Personalized Care Medicine 030212 general & internal medicine Sulfonylureas Pretreatment Risk Pioglitazone business.industry Biochemistry (medical) Hazard ratio medicine.disease Metformin business Body mass index medicine.drug |
| Popis: | Context Hypoglycemic drugs with proven cardiovascular (CV) benefits are recommended for patients with type 2 diabetes and CV disease. Whether the beneficial effects extend to those at lower risk remains unclear. Aim We investigated the long-term CV effects of pioglitazone or sulfonylureas (SUs) across the spectrum of pretreatment CV risk. Methods Among 2820 participants of the TOSCA.IT trial, four subgroups with different risk of outcome-a composite of all-cause death, nonfatal myocardial infarction, nonfatal stroke, urgent coronary revascularization-were identified by the RECursive Partitioning and AMalgamation (RECPAM) method. Within each group, the effect of SUs or pioglitazone on the outcome was evaluated. Results Sex was the first splitting variable, followed by urinary albumin-to-creatinine ratio (UACR) (>9 mg/g or ≤9 mg/g) and body mass index (BMI) (>28.7 or ≤28.7 kg/m2). Female patients had the lowest risk (reference); male patients with UACR >9 mg/g and BMI >28.7 kg/m2 had the highest risk [hazard ratio (HR), 5.58; 95% CI, 3.32 to 9.69]. Patients in this group present a cluster of conditions suggestive of marked insulin resistance (higher BMI, waist circumference, triglycerides, blood pressure, and UACR and lower high-density lipoprotein cholesterol) than the other groups. Treatment with pioglitazone in this group was associated with a significantly lower occurrence of the outcome than SUs (HR, 0.48; 95% CI, 0.25 to 0.76). No significant difference between study treatments was observed in the other RECPAM classes. Conclusions It is possible to identify patients with type 2 diabetes early in the stage of their disease and who are largely free from evident CV disease in whom add-on pioglitazone to metformin confers CV protection as compared with SUs. |
| Databáze: | OpenAIRE |
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