Surrogate Markers of Cardiovascular Risk and Chronic Obstructive Pulmonary Disease: A Large Case-Controlled Study
| Autor: | Marie Fisk, Carmel M. McEniery, Nichola Gale, Kaisa Mäki-Petäjä, Julia R. Forman, Margaret Munnery, Jean Woodcock-Smith, Joseph Cheriyan, Divya Mohan, Jonathan Fuld, Ruth Tal-Singer, Michael I. Polkey, John R. Cockcroft, Ian B. Wilkinson, Charlotte Bolton, Peter Calverley, David Lomas, William MacNee, Mellone Marchong, Bruce Miller, Sridevi Nagarajan, Zahid Dhakam, Stacey Hickson, Julia Howard, Barry McDonnell, Karen Miles, Maggie Munnery, Pawan Pusalkar, Christopher Retallick, Jane Smith, Edna Thomas, Sharon Wallace, Susannah Williams, null Yasmin |
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| Přispěvatelé: | Fisk, Marie [0000-0002-1292-7642], McEniery, Carmel [0000-0003-3636-0705], Cheriyan, Joseph [0000-0001-6921-1592], Fuld, Jonathan [0000-0003-1847-184X], Wilkinson, Ian [0000-0001-6598-9399], Apollo - University of Cambridge Repository |
| Rok vydání: | 2018 |
| Předmět: |
Male
medicine.medical_specialty carotid intima-media thickness Comorbidity 030204 cardiovascular system & hematology 1102 Cardiovascular Medicine And Haematology Corrections Risk Assessment Severity of Illness Index 03 medical and health sciences Pulmonary Disease Chronic Obstructive 0302 clinical medicine Sex Factors Vascular Stiffness Reference Values Internal medicine Internal Medicine Medicine pulse wave analysis Humans Risk factor Pulse wave velocity Aged Retrospective Studies business.industry case-control studies Incidence Smoking Case-control study Age Factors Hemodynamics 1103 Clinical Sciences Retrospective cohort study Middle Aged medicine.disease United Kingdom cardiovascular diseases Respiratory Function Tests Survival Rate Cardiovascular System & Hematology 030228 respiratory system Arterial stiffness Cardiology Biomarker (medicine) Female business Body mass index Biomarkers |
| Zdroj: | Hypertension (Dallas, Tex. : 1979) Hypertension Fisk, M, McEniery, C M, Gale, N, Mäki-Petäjä, K, Forman, J R, Munnery, M, Woodcock-smith, J, Cheriyan, J, Mohan, D, Fuld, J, Tal-singer, R, Polkey, M I, Cockcroft, J R, Wilkinson, I B 2018, ' Surrogate Markers of Cardiovascular Risk and Chronic Obstructive Pulmonary Disease : A Large Case-Controlled Study ', Hypertension, vol. 71, no. 3, pp. 499-506 . https://doi.org/10.1161/HYPERTENSIONAHA.117.10151 |
| DOI: | 10.1161/HYPERTENSIONAHA.117.10151 |
| Popis: | Cardiovascular disease is a common comorbidity and cause of mortality in chronic obstructive pulmonary disease. A better understanding of mechanisms of cardiovascular risk in chronic obstructive pulmonary disease patients is needed to improve clinical outcomes. We hypothesized that such patients have increased arterial stiffness, wave reflections, and subclinical atherosclerosis compared with controls and that these findings would be independent of smoking status and other confounding factors. A total of 458 patients with a diagnosis of chronic obstructive pulmonary disease and 1657 controls (43% were current or ex-smokers) with no airflow limitation were matched for age, sex, and body mass index. All individuals underwent assessments of carotid–femoral (aortic) pulse wave velocity, augmentation index, and carotid intima–media thickness. The mean age of the cohort was 67±8 years and 58% were men. Patients with chronic obstructive pulmonary disease had increased aortic pulse wave velocity (9.95±2.54 versus 9.27±2.41 m/s; P P P |
| Databáze: | OpenAIRE |
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