Development of a Novel Freeze-dried Mulberry Leaf Extract-based Transfersome Gel
| Autor: | Sopan Nangare, Mayuri M. Shitole, Rushikesh Mali, Dhananjay Bhatane |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
transfersomes
Drug transfersome gel Antioxidant Chromatography Chemistry medicine.medical_treatment media_common.quotation_subject Dispersity antioxidant activity lcsh:RS1-441 Pharmaceutical Science mulberry leaves Transfersome quercetin lcsh:Pharmacy and materia medica chemistry.chemical_compound Zeta potential medicine Molecular Medicine Original Article High performance thin layer chromatography Quercetin media_common Transdermal |
| Zdroj: | Turk J Pharm Sci Turkish Journal of Pharmaceutical Sciences, Vol 18, Iss 1, Pp 44-55 (2021) |
| ISSN: | 2148-6247 1304-530X |
| DOI: | 10.4274/tjps.galenos.2019.98624 |
| Popis: | OBJECTIVES: Nowadays, antioxidants are important for health-related concerns related to acne vulgaris. Acne vulgaris is interrelated with the development of free radicals that interact with cells. Mulberry leaves contain phenolic compounds, including antioxidants such as quercetin. An antioxidant is a scavenger of free radicals. The current study addresses the development of a mulberry leaf extract-based transfersome gel containing quercetin by a thin-layer hydration method for topical antioxidant delivery. The process was optimized by encapsulating the drug in a variety of transfersome formulations. MATERIALS AND METHODS: Batch optimization was carried out by particle size and zeta analysis, entrapment efficiency (%), polydispersity index, in vitro drug release, and drug content analysis. RESULTS: The optimized batch MF5 provided 86.23% entrapment efficiency of quercetin in the vesicles and 95.79% drug release. It furnished a spherical shaped vesicle with an average diameter of 118.7 nm and zeta potential of -45.11 mV. The MG1 formulation provided superior antioxidant activity, drug content, and entrapment efficiency, ex vivo drug release, spreadability, homogeneity, and stability to MG2. The presence of quercetin in the extract and gel formulation was confirmed by using high performance thin layer chromatography. CONCLUSION: It is evident from this study that a mulberry leaf extract-based transfersome gel is a promising prolonged delivery system for quercetin and has reasonably good stability characteristics. This research recommends that mulberry leaf extract-based transfersome gel can potentially be used in the treatment of acne vulgaris through a transdermal drug delivery system. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|