Antimalarial natural products of marine and freshwater origin
| Autor: | Karl Gademann, Joanna Kobylinska |
|---|---|
| Předmět: |
natural products
General Chemical Engineering Nostocarboline Plasmodium falciparum Biology Agelasine Cyanobacteria Biochemistry Natural (archaeology) Toxicology Antimalarials chemistry.chemical_compound cytotoxic Alkaloids Dragomabin Materials Chemistry medicine Animals Xestoquinone marine sponges Malaria Falciparum Biological Products antimalaria Natural product Terpenes Ecology Quinones General Chemistry medicine.disease biology.organism_classification Porifera chemistry bioactivity Peptides Malaria |
| Popis: | This review highlights recently discovered antimalarial natural products from marine and freshwater sources described in the literature from 2006 to 2008. The structures as well as bioactivities of compounds against the malaria parasites such as Plasmodium falciparum are discussed, including, for example, agelasine, xestoquinone, alisiaquinone, crambescidin, venturamide, dragomabin, gragonamide, viridamide, salinosporamide, chaetoxanthone, nodulisporacid, tumonoic acid, girolline, oroidin, nostocarboline, aerucyclamide, and microcylamide 7806 and its revised structure. Synthetic derivatives of natural products are presented including plakortin, isoaaptamine, curcuphenol, pseudopyronine, manzamine, and nostocarboline. Consequences of these discoveries for the development of novel natural product agents against malaria are discussed. |
| Databáze: | OpenAIRE |
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