IMMUNOLOGICAL MECHANISM FOR SPONTANEOUS ABORTION IN SYSTEMIC LUPUS ERYTHEMATOSUS
| Autor: | Graham R. V. Hughes, W.P Faulk, Mary Oliver, Barry Bresnihan, R.R Grigor, R.M Lewkonia, R. E. Lovins |
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| Rok vydání: | 1977 |
| Předmět: |
Abortion
Antibodies Antigen-Antibody Reactions Pregnancy immune system diseases Humans Lupus Erythematosus Systemic Medicine In patient Antigens skin and connective tissue diseases biology business.industry Mechanism (biology) Incidence (epidemiology) Antibody-Dependent Cell Cytotoxicity General Medicine Cytotoxicity Tests Immunologic Trophoblasts Abortion Spontaneous Pregnancy Complications Immunology biology.protein Female Antibody business |
| Zdroj: | The Lancet. 310:1205-1207 |
| ISSN: | 0140-6736 |
| DOI: | 10.1016/s0140-6736(77)90441-x |
| Popis: | The incidence of lymphocytotoxic antibodies in patients with systemic lupus erythematosus (S.L.E.) was significantly lower during pregnancies ending in normal live births than in pregnancies ending in spontaneous abortions (P less than 0.005). It was possible to absorb the lymphocytotoxic antibodies from S.L.E. sera with purified trophoblast antigens. The presence of a trophoblast-reactive lymphocytotoxic antibody which fails to disappear during pregnancies which end in abortion suggests an immunological mechanism for spontaneous abortion in S.L.E. |
| Databáze: | OpenAIRE |
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