Synthesis and Reactivity of α-Cumyl Bromodifluoromethanesulfenate: Application to the Radiosynthesis of [18 F]ArylSCF3

Autor:	Véronique Gouverneur, Jiang Wu, Long Lu, Qilong Shen, Stefan Verhoog, Thomas C. Wilson, Qunchao Zhao
Rok vydání:	2019
Předmět:	010405 organic chemistry Pinacol Aryl Radiosynthesis General Chemistry General Medicine 010402 general chemistry 01 natural sciences Combinatorial chemistry Catalysis Coupling reaction 0104 chemical sciences chemistry.chemical_compound chemistry Reagent Electrophile Reactivity (chemistry)
Zdroj:	Angewandte Chemie. 131:2435-2439
ISSN:	0044-8249
Popis:	A highly reactive electrophilic bromodifluoromethylthiolating reagent, α-cumyl bromodifluoro-methanesulfenate 1, was prepared to allow for direct bromodifluoromethylthiolation of aryl boron reagents. This coupling reaction takes place under copper catalysis, and affords a large range of bromodifluoromethylthiolated arenes. These compounds are amenable to various transformations including halogen exchange with [18 F]KF/K222 , a process giving access to [18 F]arylSCF3 in two steps from the corresponding aryl boronic pinacol esters.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5183fc3280346eec95208d019c9663d2 https://doi.org/10.1002/ange.201813708 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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