How does apelin affect LH levels? An investigation at the level of GnRH and KNDy neurons

Autor:	Anne Abot, Vincent Robert, Renaud Fleurot, Hugues Dardente, Vincent Hellier, Pascal Froment, Anne Duittoz, Claude Knauf, Laurence Dufourny
Rok vydání:	2022
Předmět:	Male Neurons Apelin Receptors Kisspeptins Neurokinin B Colforsin Arcuate Nucleus of Hypothalamus Luteinizing Hormone Biochemistry Dynorphins Rats Gonadotropin-Releasing Hormone Mice Endocrinology Animals Apelin Steroids Molecular Biology
Zdroj:	Molecular and cellular endocrinology. 557
ISSN:	1872-8057
Popis:	Hypothalamic control of reproduction relies on GnRH and kisspeptin (KP) secretions. KP neurons are sensitive to sex steroids and metabolic status and their distribution overlaps with neurons producing apelin, a metabolic hormone known to decrease LH secretion in rats. Here, we observed neuroanatomical contacts between apelin fibers and both KP and GnRH neurons in the hypothalamus of male rodents. Intracerebroventricular apelin infusion for 2 weeks in male mice did not decrease LH levels nor did it affect gene expression for KP, neurokinin B and dynorphin. Finally, increasing apelin concentrations did not modulate Ca
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::518209c99a2bc620ba1a2e03702cac5c https://pubmed.ncbi.nlm.nih.gov/35973528 Zobrazit plný text záznamu Full Text from ScienceDirect