Immunotherapy with oral administration of humanized anti-CD3 monoclonal antibody: a novel gut-immune system-based therapy for metaflammation and NASH
| Autor: | K Shailubhai, A Sanyal, Yaron Ilan |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
CD3 Complex medicine.drug_class medicine.medical_treatment Immunology Administration Oral Monoclonal antibody Antibodies Monoclonal Humanized digestive system T-Lymphocytes Regulatory Immune tolerance 03 medical and health sciences Mice Immune system Intestinal mucosa Oral administration Non-alcoholic Fatty Liver Disease medicine Immune Tolerance Immunology and Allergy Animals Humans Intestinal Mucosa Review Articles business.industry Liver Cirrhosis Biliary Antibodies Monoclonal Anti-CD3 monoclonal antibody Immunotherapy medicine.disease digestive system diseases 030104 developmental biology Steatohepatitis business |
| Zdroj: | Clinical and experimental immunology. 193(3) |
| ISSN: | 1365-2249 |
| Popis: | Summary The immune system plays a role in the pathogenesis of non-alcoholic steatohepatitis (NASH) underlying hepatocyte injury and fibrosis progression at all disease stages. Oral administration of anti-CD3 monoclonal antibody (mAb) has been shown in preclinical studies to be an effective method for systemic immune modulation and alleviates immune-mediated disorders without T cell depletion. In the present review, we summarize the concept of the oral administration of humanized anti-CD3 mAb in patients with NASH and discuss the potential of this treatment to address the current requirements of treatments for NASH. Recently published preclinical and clinical data on oral administration of anti CD3 are discussed. Human trials have shown that the oral administration of anti-CD3 in healthy volunteers, patients with chronic hepatitis C virus (HCV) infection and patients with NASH and type 2 diabetes is safe and well tolerated, as well as biologically active. Oral anti-CD3 induces regulatory T cells, suppresses the chronic inflammatory state associated with NASH and exerts a beneficial effect on clinically relevant parameters. Foralumab is a fully human anti-CD3 mAb that has recently been shown to exert a potent anti-inflammatory effect in humanized mice. It is being developed for treatment of NASH and primary biliary cholangitis (PBC). Oral administration of anti CD3 may provide an effective therapy for patients with NASH. |
| Databáze: | OpenAIRE |
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