The potential role of follicular helper T cells in idiopathic multicentric Castleman disease with and without TAFRO syndrome
| Autor: | Hiroshi Kawabata, Shino Fujimoto, Akihiro Shioya, Shigeo Nakamura, Kazue Takai, Xin Guo, Nozomu Kurose, Yasufumi Masaki, Kenichi Mizutani, Motona Kumagai, Sohsuke Yamada, Sadao Aoki |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Pathology medicine.medical_specialty Plasma Cells CD38 CXCR5 Pathology and Forensic Medicine 03 medical and health sciences 0302 clinical medicine medicine Humans Retrospective Studies CD40 biology Follicular dendritic cells urogenital system business.industry Castleman Disease Germinal center Cell Biology T-Lymphocytes Helper-Inducer medicine.disease 030104 developmental biology Immunoglobulin class switching 030220 oncology & carcinogenesis Immunoglobulin G biology.protein IgG4-related disease Antibody business |
| Zdroj: | Pathology, research and practice. 215(10) |
| ISSN: | 1618-0631 |
| Popis: | Idiopathic multicentric Castleman disease (iMCD) is a systemic inflammatory disease of unknown etiology caused by hypercytokinemia. Recently, TAFRO ( t hrombocytopenia, a nasarca, f ever, r enal failure or r eticulin fibrosis, and o rganomegaly) syndrome has been reported, which shows similar histopathological findings to iMCD and factors associated with a poor prognosis. iMCD shows no plasma cell infiltration in the germinal center (GC), but CD38-positive (CD38+)-plasma cells are observed in the interfollicular area. Our previous report revealed that atrophic change of GC, glomeruloid vascular proliferation, and abnormal proliferation of follicular dendritic cells are more prominent in iMCD with TAFRO (TAFRO+) in comparison to iMCD without TAFRO (TAFRO−). In addition, the numbers of CD38+ and immunoglobulin G4-positive (IgG4+) plasma cells were decreased in the interfollicular area. The roles of T follicular helper cells (Tfh) are well-known to assist B-cell proliferation, maturation, and differentiation．It maintains the formation of GC and is also related in the class switching of IgG isotypes, including IgG4. Thus, we immunohistochemically examined the number of Tfh in GCs in both TAFRO− and TAFRO+ iMCD. The number of Tfh was significantly decreased in TAFRO− iMCD (n = 9) and was further decreased in TAFRO+ iMCD (n = 18) in comparison to non-specific lymphadenopathy (n = 6) and IgG4-related disease (n = 4). These results suggest that decreased Tfh may be one etiology of iMCD. |
| Databáze: | OpenAIRE |
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